PMID: 375802Mar 1, 1979Paper

Cefazolin prophylaxis in head and neck cancer surgery

The Annals of Otology, Rhinology, and Laryngology
G D Becker, G J Parell

Abstract

This study evaluated the prophylactic use of cefazolin in reducing the incidence of infection in patients undetgoing cancer surgery where the upper aerodigestive tract was entered from the neck. A prospective, randomized, double-blind design was conducted in a single hospital. The patient was given placebo or cefazolin, 1 gm intramuscularly with the preoperative medications, then 0.5 gm every six hours for four doses. Of 55 determinate patients, 32 received antibiotics and 23 placebo. Infection rate was 38% (12/32) and 87% (20/23) respectively, representing a statistically significant reduction in infection (P less than 0.001/. There were 30 wound and two nonwound (sinusitis and pneumonia) infections. In conclusion, the perioperative use of cefazolin in patients undergoing cancer surgery where the oral cavity or pharynx has been entered from the neck is useful in reducing the incidence of wound infection.

References

Mar 1, 1977·Archives of Surgery·G W Chodak, M E Plaut
Apr 1, 1975·The Journal of Infectious Diseases·V L Sutter, S M Finegold
Oct 1, 1977·Southern Medical Journal·H C Neu
Oct 1, 1976·Antimicrobial Agents and Chemotherapy·D F BuschS M Finegold
Oct 7, 1974·JAMA : the Journal of the American Medical Association·J R Caldwell, L E Cluff
May 1, 1971·The British Journal of Surgery·A E DavidsonG Smith
Aug 1, 1964·Annals of Surgery·J E RHOADS

❮ Previous
Next ❯

Citations

Jan 26, 2012·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·William ScottonRicard Simo
May 15, 2004·Current Infectious Disease Reports·Rebecca Fraioli, Jonas T. Johnson
Oct 20, 1999·International Journal of Antimicrobial Agents·D L Callender
Oct 27, 2015·Surgical Infections·Samir S KhariwalaJeffrey G Chipman
Apr 10, 2013·Annales Françaises D'anesthèsie Et De Rèanimation·M GarnierC Quesnel
Jun 9, 2009·International Journal of Pediatric Otorhinolaryngology·Satyamaanasa PolubothuHaytham Kubba
Jul 8, 2008·Oral and Maxillofacial Surgery Clinics of North America·Jon D Holmes
Jun 15, 2011·The Laryngoscope·Li-Xing ManJonas T Johnson
May 4, 2004·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Luca LazzariniFausto de Lalla
Dec 1, 1984·Annals of Emergency Medicine·J A Sharff
Jan 12, 2010·Acta otorrinolaringológica española·Sergio ObesoCarlos Suárez
Nov 2, 2014·Acta Microbiologica Et Immunologica Hungarica·Márta PatyiFerenc Oberna
Jan 23, 2015·HNO·C ThornB A Stuck
Jul 10, 2004·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Seth R SchwartzShukri F Khuri
Oct 1, 1984·Clinical Otolaryngology and Allied Sciences·A C SwiftJ E Corkill
Apr 1, 1984·Clinical Otolaryngology and Allied Sciences·C A BartzokasG M Trafford-Jones
Jul 1, 1983·The Annals of Otology, Rhinology, and Laryngology·R K NewmanL W Gumerman
Nov 18, 2015·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Christopher PoolBrett A Miles
May 20, 1998·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·L BalbuenaC Yeager
Jul 12, 2017·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Peter M VilaRyan S Jackson
Feb 7, 2018·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Priyesh N PatelDavid O Francis
Aug 1, 1990·Clinical Otolaryngology and Allied Sciences·R P MortonE B Dorman
Mar 10, 2018·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Sheran SeneviratneDaron Cope
Mar 23, 2006·Current Opinion in Otolaryngology & Head and Neck Surgery·Ricard Simo, Gary French
Jul 1, 1997·The Journal of Laryngology and Otology·M StraussA L Allphin
Nov 1, 1994·The Journal of Laryngology and Otology·M I Redleaf, C A Bauer
Mar 22, 2006·Archives of Facial Plastic Surgery·Lisa Danielle Grunebaum, David Reiter
Dec 1, 1986·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·J T JohnsonR L Wagner
Dec 1, 1984·Journal of the Royal Society of Medicine·C H RaineJ E Corkill
Dec 11, 1991·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·E S ElledgeK I Stambaugh
Sep 1, 1984·Pharmacotherapy·T G Burnakis
Jan 1, 1992·The Annals of Otology, Rhinology & Laryngology. Supplement·R S Weber, D L Callender
Jan 1, 1993·The Journal of Laryngology and Otology·E Mustafa, A Tahsin
Mar 1, 1990·Head & Neck·K T RobbinsR Cole
May 1, 1981·The Annals of Otology, Rhinology & Laryngology. Supplement·G D Becker
Mar 20, 2008·The Journal of Trauma·Kyle PetersenRobert G Hale
Jun 1, 1984·Infection Control : IC·G V RobinsonJ A Zaia

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.