PMID: 9660993Jul 14, 1998Paper

Cefepime-aztreonam: a unique double beta-lactam combination for Pseudomonas aeruginosa

Antimicrobial Agents and Chemotherapy
Philip D ListerC C Sanders

Abstract

An in vitro pharmacokinetic model was used to determine if aztreonam could enhance the pharmacodynamics of cefepime or ceftazidime against an isogenic panel of Pseudomonas aeruginosa 164, including wild-type (WT), partially derepressed (PD), and fully derepressed (FD) phenotypes. Logarithmic-phase cultures were exposed to peak concentrations achieved in serum with 1- or 2-g intravenous doses, elimination pharmacokinetics were simulated, and viable bacterial counts were measured over three 8-h dosing intervals. In studies with cefepime and cefepime-aztreonam against the PD strain, samples were also filter sterilized, assayed for active cefepime, and assayed for nitrocefin hydrolysis activity before and after overnight dialysis. Against WT strains, the cefepime-aztreonam combination was the most active regimen, but viable counts at 24 h were only 1 log below those in cefepime-treated cultures. Against PD and FD strains, the antibacterial activity of cefepime-aztreonam was significantly enhanced over that of each drug alone, with 3.5 logs of killing by 24 h. Hydrolysis and bioassay studies demonstrated that aztreonam was inhibiting the extracellular cephalosporinase that had accumulated and was thus protecting cefepime in the extr...Continue Reading

References

Jun 1, 1979·Antimicrobial Agents and Chemotherapy·C C Sanders, W E Sanders
Aug 1, 1990·The Journal of Infectious Diseases·G L DaikosD M Livermore
Feb 1, 1990·The Journal of Antimicrobial Chemotherapy·M AkovaD M Livermore
Jan 1, 1988·Clinical Microbiology Reviews·K Bush
Sep 1, 1986·Antimicrobial Agents and Chemotherapy·M L GatesW E Sanders
Apr 1, 1986·The Journal of Antimicrobial Chemotherapy·H C NeuP Labthavikul
Dec 1, 1986·Antimicrobial Agents and Chemotherapy·C C SandersE S Moland
May 1, 1986·Antimicrobial Agents and Chemotherapy·D J PhelpsR E Kessler
Feb 1, 1985·Antimicrobial Agents and Chemotherapy·R E KesslerF Leitner
May 1, 1985·Antimicrobial Agents and Chemotherapy·P C FuchsC Thornsberry
Jan 1, 1985·The Journal of Antimicrobial Chemotherapy·J BlaserS H Zinner
Apr 1, 1972·Antimicrobial Agents and Chemotherapy·C H O'CallaghanA H Shingler
Sep 1, 1982·Antimicrobial Agents and Chemotherapy·K BushR B Sykes
Jun 1, 1995·Antimicrobial Agents and Chemotherapy·K BushA A Medeiros

❮ Previous
Next ❯

Citations

Nov 8, 2002·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·Philip D Lister
Jul 16, 2004·The Kaohsiung Journal of Medical Sciences·Yen-Hsu ChenTyen-Po Chen
Jun 28, 2013·Pharmacological Reviews·Elisabet I Nielsen, Lena E Friberg
Aug 18, 2017·Medicinal Research Reviews·Lena DecuyperStanislav Gobec
Feb 16, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Philip D Lister, Daniel J Wolter
Mar 16, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P D Lister
Jun 24, 2016·The Journal of Antimicrobial Chemotherapy·Christopher Ramsey, Alasdair P MacGowan
Nov 30, 2018·The Pediatric Infectious Disease Journal·Jamie L MillerRobert C Welliver
Mar 3, 2004·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Daisuke Kataoka, Yoshinori Tanaka
Jul 10, 2003·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·E BernardG Potel

❮ Previous
Next ❯

Related Concepts

Related Feeds

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.