PMID: 6975269Feb 1, 1981Paper

Cefonicid: a stable beta-lactamase inhibitor

The Journal of Antibiotics
R J MehtaP Actor

Abstract

The stability of cefonicid (SK&F 75073) towards representatives of six major classes of beta-lactamases was determined using a spectrophotometric assay. Cefonicid was stable to hydrolysis by the Type I enzyme from Enterobacter cloacae and by the enzyme from the anaerobe, Bacteroides fragilis. It was 6 to 7 times more stable than cefamandole to the Type IIIA and B enzymes from Escherichia coli, a little less stable than this antibiotic to the Type V enzyme from E. coli, and of equal stability to the Type IV enzyme from Klebsiella aerogenes. Cefonicid was a non-competitive inhibitor (Ki of 0.8 x 10(-6)M) of cephalothin hydrolysis by the Type I enzyme.

Citations

Mar 1, 1985·Drug Intelligence & Clinical Pharmacy·T A Tartaglione, R E Polk
Jun 1, 1982·Antimicrobial Agents and Chemotherapy·S L BarriereJ E Conte
Feb 1, 1983·Journal of Clinical Microbiology·A L BarryC Thornsberry

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