Cefoperazone in the treatment of peritonitis in continuous ambulatory peritoneal dialysis patients

Artificial Organs
D J LeeheyT S Ing

Abstract

Cefoperazone is a third-generation cephalosporin that is active against a broad spectrum of gram-positive and gram-negative bacteria. We added this antibiotic to peritoneal dialysis solution at a concentration of 62.5 mg/L to treat peritonitis in six continuous ambulatory peritoneal dialysis (CAPD) patients. Serum drug concentrations were obtained at 0, 0.5, 1, 2, 4, and 24 h after instituting antibiotic therapy. Rapid uptake by blood of the antibiotic across the peritoneal membrane occurred when the latter was inflamed. Adequate bactericidal serum levels for many bacteria were obtained in less than 4 h. Cefoperazone effectively eradicated peritonitis in all patients.

References

Feb 1, 1984·Clinical Pharmacology and Therapeutics·E KellerP Schollmeyer
Jun 1, 1982·The Journal of Antimicrobial Chemotherapy·R Gokal

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Citations

Jan 1, 1990·Biomaterials, Artificial Cells, and Artificial Organs·Y T Yu, C Z Chen
Apr 29, 2014·The Cochrane Database of Systematic Reviews·Angela E BallingerGiovanni F M Strippoli
Jun 11, 2016·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Philip Kam-Tao LiDavid W Johnson

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