PMID: 3768489Jul 1, 1986Paper

Ceforanide pharmacokinetics in haemodialysis: the effect of ultrafiltration

Biopharmaceutics & Drug Disposition
J M LanaoJ R Gómez

Abstract

The kinetics of ceforanide in plasma and dialysate was studied in 8 patients with terminal renal impairment after undergoing haemodialysis sessions lasting between 4 and 5 h. All patients received a single i.v. dose of 15 mg kg-1 of the drug at the start of the session. The dialysers used in this study were Spiraflow capillar 1.3 m2, Travenol plates 1.4 m2, and PAN plates. Blood flow ranged between 200 and 300 ml min-1 and dialysate flow between 500-650 ml min-1. Plasma ceforanide levels were measured at the input and output of the dialyser and the antibiotic levels in dialysate were determined coinciding with the withdrawal times of the blood samples. A microbiologic plate diffusion method was used to determine the antibiotic concentrations. The mean values of some pharmacokinetic parameters of ceforanide calculated with a non-linear regression program from the data obtained from arterial blood were the following: alpha (h-1) = 4.14 +/- 1.32; beta (h-1) = 0.26 +/- 0.07; t1/2 beta (h) = 2.82 +/- 0.82; Vdss (1) = 10.24 +/- 2.14. From the relationships between the antibiotic concentrations at the input and output of the dialyser it was possible to calculate an extraction coefficient of 0.11 +/- 0.06. The dialysis clearance of cef...Continue Reading

References

Aug 1, 1979·European Journal of Clinical Pharmacology·A Dominguez-GilS de Castro
Sep 1, 1976·Antimicrobial Agents and Chemotherapy·F LeitnerK E Price
Apr 1, 1973·Journal of Pharmacokinetics and Biopharmaceutics·M Pfeffer
Jan 1, 1983·European Journal of Clinical Pharmacology·M J NietoJ F Macias
Apr 1, 1982·Biopharmaceutics & Drug Disposition·C S Lee
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Feb 1, 1980·Antimicrobial Agents and Chemotherapy·J R HessA M Siemsen

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