Cefoxitin Prophylaxis During Pediatric Cardiac Surgery: Retrospective Exploration of Postoperative Trough Levels

The Pediatric Infectious Disease Journal
Zaccaria RicciBianca Goffredo

Abstract

This study aimed to explore inter-individual variability of cefoxitin trough levels, predictors of serum cefoxitin concentration and the probability of target attainment of drug levels above 4 mg/L after pediatric cardiac surgery. Retrospective study on children scheduled for elective cardiac surgery and having cefoxitin trough levels available up to 24 hours postsurgery. Overall, 68 children (9 neonates, 34 infants, 15 children below or equal to 10 years old and 10 patients above this age) were included. Of these, 16 surgeries were performed off cardiopulmonary bypass and 52 were performed on cardiopulmonary bypass. The free cefoxitin concentrations showed a median (interquartile range) concentration of 1.7 (0.6-4.2) mg/L. The range of cefoxitin concentrations showed a 150-fold and 340-fold variability at cardiac intensive care unit admission and after 24 hours, respectively. The pharmacodynamics (PD) targets of free cefoxitin at 100% of the dosing interval, considering Eucast breakpoints for Methicillin Sensitive Staphylococcus Aureus (4 mg/L) and E.Coli (8 mg/L), were obtained in 28% and 16% of patients, respectively. Patient weight (odds ratio, 0.7; 95% confidence interval, 0.62-0.92; P = 0.006) and serum creatinine concent...Continue Reading

References

Jan 1, 1983·European Journal of Clinical Pharmacology·M B RegazziR Rondanelli
Feb 10, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·W A Craig
Nov 5, 2004·American Journal of Infection Control·Alireza NateghianJoan L Robinson
Oct 2, 2009·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Michael G GaiesJennifer C Hirsch
Feb 23, 2010·The Annals of Thoracic Surgery·Gregory M BarkerJennifer S Li
Sep 25, 2010·Journal of Cardiothoracic and Vascular Anesthesia·Chad A KnodererKevin M Sowinski
Jan 17, 2012·European Journal of Clinical Pharmacology·Arantxazu IslaAlicia Rodríguez Gascón
Apr 19, 2012·Critical Care Medicine·Darren M RobertsUNKNOWN RENAL Replacement Therapy Study Investigators
Nov 2, 2012·Paediatrics & Child Health·Shinya Ito
Jan 19, 2013·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Dale W BratzlerUNKNOWN Society for Healthcare Epidemiology of America
Jan 17, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jason A RobertsUNKNOWN DALI Study
Feb 14, 2014·The Journal of Thoracic and Cardiovascular Surgery·Jennifer H HuangStephen M Langley
Dec 5, 2016·Journal of the American College of Surgeons·Kristen A BanTherese M Duane
Mar 4, 2017·International Journal of Antimicrobial Agents·Fathima ParukJason A Roberts
Apr 8, 2017·The Journal of Antimicrobial Chemotherapy·Pieter A J G De CockPeter De Paepe
Jun 24, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Sean N AvedissianJennifer Le
Nov 8, 2017·Critical Care Medicine·Jeffrey J CiesArun Chopra

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Citations

Mar 30, 2020·The Pediatric Infectious Disease Journal·Zaccaria RicciPaola Milla

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