Ceftazidime, gentamicin, and rifampicin, in combination, kill biofilms of mucoid Pseudomonas aeruginosa

Canadian Journal of Microbiology
M Ghani, J S Soothill

Abstract

In continuous flow biofilm cultures in medium resembling cystic fibrosis bronchial secretions, Pseudomonas aeruginosa was not eradicated from biofilms by 1 week of treatment with high concentrations of ceftazidime and gentamicin, to which the strains were sensitive on conventional testing. The addition of rifampicin, which has little activity against the strains as measured by the minimum inhibitory concentration, led to the apparent elimination of the bacteria from the biofilms. The effect was not strain specific.

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Citations

Jul 5, 2006·Journal of Mathematical Biology·Julia HesselerDietrich Flockerzi
Sep 18, 2007·Journal of Bacteriology·Kelli L PalmerMarvin Whiteley
Dec 16, 2006·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Hiroshi Tanaka
May 25, 2012·Proteomics·Sabine KlugeUdo Reichl
Mar 8, 2006·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Mustafa A AlkawashNeal L Schiller
Feb 22, 2012·Expert Review of Anti-infective Therapy·Joanne L FothergillChloe E James
Jun 11, 2005·Journal of Medical Microbiology·Dinesh D SriramuluUte Römling
Aug 2, 2005·Clinical Orthopaedics and Related Research·Robin Patel
Nov 20, 2020·International Journal of Molecular Sciences·Pongsiri JaikumpunÁkos Zsembery
Sep 18, 2018·Molecular Pharmaceutics·Hairui ZhangHugh D C Smyth

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