Ceftobiprole activity when tested against contemporary bacteria causing bloodstream infections in the United States (2016-2017)

Diagnostic Microbiology and Infectious Disease
Michael A PfallerH S Sader

Abstract

Ceftobiprole medocaril, the prodrug of ceftobiprole, is an advanced-generation cephalosporin that is approved in many European and non-European countries for the treatment of adults with hospital-acquired pneumonia (excluding ventilator-associated pneumonia) and community-acquired pneumonia and is currently being evaluated in a global phase 3 clinical trial of patients with Staphylococcus aureus bacteremia. This study investigated the in vitro activity of ceftobiprole and comparators against a total of 5466 gram-positive and -negative isolates from bloodstream infections (BSIs) that were collected in the United States during 2016 and 2017 as part of the SENTRY Antimicrobial Surveillance Program. Ceftobiprole was highly active (isolates were >99% susceptible) against S. aureus (including methicillin-resistant S. aureus), coagulase-negative staphylococci, Enterococcus faecalis, streptococci, and non-extended-spectrum β-lactamase (non-ESBL) phenotype Enterobacteriaceae. As expected, lower activities were observed against Enterococcus faecium, ESBL-phenotype Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter baumannii. These results support further clinical evaluation of ceftobiprole for the treatment of BSIs caused by s...Continue Reading

Citations

Oct 10, 2019·Expert Opinion on Drug Metabolism & Toxicology·Manon TauzinRobert Cohen
Mar 18, 2020·Antimicrobial Agents and Chemotherapy·Robert K FlammMichael A Pfaller
Sep 9, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J Scott OvercashKamal A Hamed
Mar 11, 2020·Antimicrobial Agents and Chemotherapy·Vijay KumarFocco van den Akker
Jul 3, 2021·Life·Roberto GiurazzaEmanuele Durante-Mangoni
Oct 1, 2021·Frontiers in Microbiology·Vladimir GostevSergey Sidorenko

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