Ceftobiprole: in-vivo profile of a bactericidal cephalosporin

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
Henry F Chambers

Abstract

Resistance to antimicrobials is a significant and growing problem, limiting treatment options, especially for serious Gram-positive infections. Ceftobiprole is a novel broad-spectrum cephalosporin that is active in vitro against streptococci and staphylococci, including penicillin-resistant strains of pneumococci and methicillin-resistant Staphylococcus aureus (MRSA). It maintains the activity of extended-spectrum cephalosporins against Gram-negative bacteria, including Enterobacteriaceae. The in-vivo activity of ceftobiprole has been demonstrated in mouse sepsis and subcutaneous abscess models of infection. Its activity also has been examined in several discriminative models of infection that mimic specific diseases in humans and permit testing of antimicrobial activity under a variety of defined pharmacokinetic conditions. These include experimental pneumonia in mice, a tissue cage model of foreign body infection in rats, and endocarditis models in rats and rabbits. In these models, ceftobiprole exhibits activity equivalent or superior to that of comparators against MRSA, including vancomycin-intermediate strains. These models also confirm the in-vivo activity of ceftobiprole against Gram-negative bacteria that are susceptibl...Continue Reading

References

Sep 25, 2001·The Journal of Hospital Infection·J M Schierholz, J Beuth
Feb 28, 2003·Expert Opinion on Investigational Drugs·Darren AbbanatKaren Bush
Oct 18, 2003·The Journal of Antimicrobial Chemotherapy·Bulent BozdoganPeter C Appelbaum
Nov 18, 2003·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·L M Deshpande, R N Jones
Jun 5, 2004·Clinics in Laboratory Medicine·Peter C Appelbaum, Bülent Bozdogan
Jun 25, 2004·Antimicrobial Agents and Chemotherapy·Anne Schmitt-HoffmannPéter Kovács
Jun 25, 2004·Antimicrobial Agents and Chemotherapy·Anne Schmitt-HoffmannErhard Weidekamm
Sep 10, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S E CosgroveT M Perl
Oct 23, 2004·Emerging Infectious Diseases·Edine W TiemersmaUNKNOWN European Antimicrobial Resistance Surveillance System Participants
Jan 11, 2005·Current Opinion in Infectious Diseases·Gregory M Anstead, Aaron D Owens
Jun 7, 2005·Expert Opinion on Therapeutic Targets·John F Barrett
Sep 29, 2005·Antimicrobial Agents and Chemotherapy·Tatiana BogdanovichPeter C Appelbaum

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Citations

Feb 7, 2008·Expert Review of Anti-infective Therapy·William J PeppardAngela M Urmanski
Sep 9, 2009·Expert Review of Anti-infective Therapy·Patricia L Schirmer, Stanley C Deresinski
Nov 1, 2009·Expert Review of Clinical Pharmacology·Knut Ohlsen
Jul 1, 2008·Expert Review of Clinical Pharmacology·Tina Q Tan, Ram Yogev
Jan 1, 2007·Expert Opinion on Drug Discovery·Malcolm Gp Page
Mar 7, 2008·Expert Opinion on Investigational Drugs·Matteo BassettiClaudio Viscoli
May 2, 2009·International Journal of Antimicrobial Agents·Sara MartiJordi Vila
Apr 4, 2008·Diagnostic Microbiology and Infectious Disease·Stanley C Deresinski
Apr 4, 2008·Diagnostic Microbiology and Infectious Disease·Thomas P LodiseRonald N Jones
Mar 10, 2007·International Journal of Antimicrobial Agents·Abhijit M Bal, Ian M Gould
Jan 29, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Dimitrios P KontoyiannisKieren Marr
Feb 12, 2008·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·D Y Aksoy, S Unal
Apr 9, 2008·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C K Naber
Feb 7, 2009·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·B HellmarkB Söderquist
May 10, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·F W Goldstein
May 10, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M E Jones
May 11, 2016·Journal of Enzyme Inhibition and Medicinal Chemistry·Lifang SiLixin Luo
Jan 30, 2010·The Journal of Antimicrobial Chemotherapy·Nuno SilvaPatrícia Poeta
Sep 19, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Scott T Micek
Jan 30, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Gary J NoelRichard S Strauss
Mar 11, 2015·Antimicrobial Agents and Chemotherapy·Liana C ChanHenry F Chambers
Apr 14, 2016·Antimicrobial Agents and Chemotherapy·Liana C ChanSom S Chatterjee
Dec 13, 2006·Nature Reviews. Drug Discovery·Lynn L Silver
Oct 14, 2008·Expert Review of Anti-infective Therapy·Natasha V D V Ratnaraja, Peter M Hawkey
Jul 4, 2007·The Journal of Antimicrobial Chemotherapy·Cesar A AriasBarbara E Murray
Mar 23, 2020·Annals of Clinical Microbiology and Antimicrobials·Claire DuployezCaroline Loiez
Oct 4, 2016·Expert Review of Anti-infective Therapy·Amelia DeitchmanHartmut Derendorf

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