Ceftobiprole is superior to vancomycin, daptomycin, and linezolid for treatment of experimental endocarditis in rabbits caused by methicillin-resistant Staphylococcus aureus.

Antimicrobial Agents and Chemotherapy
P TattevinH F Chambers

Abstract

Beta lactam agents are the most active drugs for the treatment of streptococci and methicillin-susceptible Staphylococcus aureus endocarditis. However, methicillin-resistant S. aureus (MRSA) is resistant to all beta lactam agents licensed to date, and alternative treatments are limited. Ceftobiprole is a novel broad-spectrum cephalosporin that binds with high affinity to PBP 2a, the penicillin binding protein that mediates the methicillin resistance of staphylococci and is active against MRSA. Ceftobiprole was compared to vancomycin, daptomycin, and linezolid in a rabbit model of MRSA aortic valve endocarditis caused by the homogeneously methicillin-resistant laboratory strain COL. Residual organisms in vegetations were significantly fewer in ceftobiprole-treated rabbits than in any other treatment group (P<0.05 for each comparison). In addition, the numbers of organisms in spleens and in kidneys were significantly lower in ceftobiprole-treated rabbits than in linezolid- and vancomycin-treated animals (P<0.05 for each comparison). Anti-MRSA beta lactam agents such as ceftobiprole may represent a significant therapeutic advance over currently available agents for the treatment of MRSA endocarditis.

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Citations

Nov 21, 2013·International Journal of Antimicrobial Agents·Darren AbbanatA Simon Lynch
Sep 14, 2013·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Y BarneaY Carmeli
May 3, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Pierre TattevinRémy Gauzit
Mar 23, 2013·International Journal of Medical Microbiology : IJMM·Michael Otto
Apr 12, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Samir S AwadMarc Engelhardt
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May 24, 2016·International Journal of Antimicrobial Agents·Chiara OltoliniPaolo Scarpellini
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Oct 18, 2019·Expert Opinion on Pharmacotherapy·Matteo BassettiMaddalena Peghin
Mar 23, 2020·Annals of Clinical Microbiology and Antimicrobials·Claire DuployezCaroline Loiez
Aug 22, 2020·Infection and Drug Resistance·Ebrahim MahmoudAdel Alothman
Sep 26, 2019·Expert Review of Anti-infective Therapy·Daniele Roberto GiacobbeMatteo Bassetti
Feb 12, 2021·Antibiotics·Tommaso LupiaFrancesco Giuseppe De Rosa

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