Abstract
Urinary tract infections (UTI) are a major public health problem among spinal cord injury (SCI) patients. They frequently involve multidrug-resistant (MDR) bacteria. Ceftolozane/tazobactam (C/T) is a novel antibiotic combination approved for complicated intra-abdominal and UTI caused by Gram-positive and Gram-negative organisms, including some MDR strains. Little is known about the use of this agent for complicated febrile UTI occurring among SCI patients with neurogenic bladder due to MDR Pseudomonas aeruginosa (PSA). We describe the case of a 35-year-old man with SCI due to multiple sclerosis, with a neurogenic bladder necessitating a bilateral nephrostomy and double J catheter, who developed a febrile UTI due to a MDR PSA, which was susceptible only to amikacin and colistin. Because of this MDR phenotype and the underlying kidney disease, a 1000 mg (1000 mg per 500 mg) dose of C/T was given as monotherapy every 8 h for 7 days, after 3 days of colistin and amikacin. Thanks to this treatment, the patient had a favorable outcome with no clinical signs of UTI or positive urine culture up to 1 month after diagnosis. C/T seems to be an effective and safe therapeutic option for febrile UTI due to MDR PSA in SCI patients with neurog...Continue Reading
References
Dec 20, 1999·The Journal of Antimicrobial Chemotherapy·S OieH Mizuno
Apr 24, 2003·Antimicrobial Agents and Chemotherapy·James A KarlowskyDaniel F Sahm
Sep 5, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Cheol-In KangKang-Won Choe
Oct 31, 2003·The Journal of Antimicrobial Chemotherapy·Shigeharu OieAkira Kamiya
Nov 25, 2004·Antimicrobial Agents and Chemotherapy·Marilee D ObritschRose Jung
Sep 28, 2005·Pharmacotherapy·Marilee D ObritschRose Jung
Dec 30, 2006·Antimicrobial Agents and Chemotherapy·Regina B OsihAnthony D Harris
Jul 25, 2007·Antimicrobial Agents and Chemotherapy·Thomas P LodiseJessina C McGregor
Feb 23, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Thomas M HootonUNKNOWN Infectious Diseases Society of America
Sep 20, 2011·Pharmacotherapy·Kristi A TraugottJames S Lewis
Jul 4, 2012·Antimicrobial Agents and Chemotherapy·Laura MorataJosé Mensa
Oct 9, 2013·Antimicrobial Agents and Chemotherapy·David J FarrellRonald N Jones
Nov 6, 2014·Antimicrobial Resistance and Infection Control·Dilip NathwaniVandana Menon
Feb 3, 2015·Seminars in Respiratory and Critical Care Medicine·Kate McCarthy
Feb 12, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Joseph SolomkinChristian Eckmann
May 2, 2015·Lancet·Florian M WagenlehnerRabih O Darouiche
Feb 18, 2016·Spinal Cord·A DinhL Bernard
Apr 17, 2016·BMC Infectious Diseases·Aurélien DinhLouis Bernard
May 4, 2016·Antimicrobial Agents and Chemotherapy·Benjamin MillerJohn Alverdy
Dec 14, 2016·Antimicrobial Agents and Chemotherapy·Juan José CastónJulián Torre-Cisneros
Citations
Mar 2, 2018·Expert Review of Anti-infective Therapy·Daniele Roberto GiacobbeUNKNOWN ISGRI-SITA (Italian Study Group on Resistant Infections of the Società Italiana Terapia Antinfettiva)
Feb 21, 2019·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Marcello Torres da SilvaPaulo Sergio Siebra Beraldo
Apr 10, 2021·Antimicrobial Resistance and Infection Control·Laura PuzniakAshley Enstone