Ceftolozane/tazobactam for the treatment of multidrug resistant Pseudomonas aeruginosa: experience from the Balearic Islands.

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
Manuel Díaz-CañestroAntonio Oliver

Abstract

A prospective, descriptive observational study of consecutive patients treated with ceftolozane/tazobactam in the reference hospital of the Balearic Islands (Spain), between May 2016 and September 2017, was performed. Demographic, clinical, and microbiological variables were recorded. The later included resistance profile, molecular typing, and whole genome sequencing of isolates showing resistance development. Fifty-eight patients were treated with ceftolozane/tazobactam. Thirty-five (60.3%) showed respiratory tract infections, 21 (36.2%) received monotherapy, and 37 (63.8%) combined therapy for ≥ 72 h, mainly with colistin (45.9%). In 46.6% of the patients, a dose of 1/0.5 g/8 h was used, whereas 2/1 g/8 h was used in 41.4%. In 56 of the cases (96.6%), the initial Pseudomonas aeruginosa isolates recovered showed a multidrug resistant (MDR) phenotype, and 50 of them (86.2%) additionally met the extensively drug resistant (XDR) criteria and were only susceptible colistin and/or aminoglycosides (mostly amikacin). The epidemic high-risk clone ST175 was detected in 50% of the patients. Clinical cure was documented in 37 patients (63.8%) and resistance development in 8 (13.8%). Clinical failure was associated with disease severity ...Continue Reading

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Citations

Apr 25, 2019·Antibiotics·Justin R LenhardKeith S Kaye
Nov 20, 2019·Antimicrobial Agents and Chemotherapy·Pablo A Fraile-RibotUNKNOWN GEMARA-SEIMC/REIPI Pseudomonas Study Group
Mar 28, 2020·Expert Opinion on Pharmacotherapy·Ibai Los-ArcosBenito Almirante
Nov 18, 2020·Antimicrobial Agents and Chemotherapy·Damien FournierUNKNOWN GERPA Study Group
Dec 22, 2020·International Journal of Antimicrobial Agents·Bárbara BalandinAna Royuela
Nov 13, 2020·Clinical Microbiology Reviews·Dafna YahavLeonard Leibovici
Apr 3, 2021·Open Forum Infectious Diseases·Delaney E HartUNKNOWN C/T Alliance to deliver Real-world Evidence (CARE)
Apr 10, 2021·Antimicrobial Resistance and Infection Control·Laura PuzniakAshley Enstone
Apr 21, 2021·Antimicrobial Agents and Chemotherapy·Bryan D LizzaMarin H Kollef
May 12, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Geneva M WilsonUNKNOWN QUERI CARRIAGE Program
Oct 13, 2021·Current Opinion in Infectious Diseases·Matteo BassettiDaniele Roberto Giacobbe
Jan 1, 2022·International Journal of Antimicrobial Agents·Lorenzo OnoratoNicola Coppola

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Methods Mentioned

BETA
electrophoresis

Software Mentioned

GraphPad Prism
IMB
SPSS® Statistics
HUSE

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