PMID: 8453025Mar 1, 1993Paper

Ceftriaxone pharmacokinetics in elderly subjects and penetration into epididymis

Biopharmaceutics & Drug Disposition
F GenyM Galtier

Abstract

In a prospective study, the epididymal penetration of ceftriaxone was evaluated in order to use it in the treatment of orchi-epididymitis in men. A bolus intravenous dose of 1 g of ceftriaxone was administered to 15 patients hospitalized for surgery as part of treatment for prostatic adenoma or prostatic cancer. Nine successive blood samples were collected in the interval from 0 to 24 h after administration, and epididymis samples were taken 0.75 h after administration. Concentrations of drug in all samples were assayed by a reverse-phase-ion pairing high-performance liquid chromatography method with UV detection. The results showed that the pharmacokinetics of ceftriaxone in serum did not differ from those determined previously in healthy volunteers. The terminal half-life was 6.9 +/- 1.7 h, and the mean residence time 9.5 +/- 2.3 h. The volume of distribution was 0.144 +/- 0.018 1 kg-1 and the total body clearance 1.17 +/- 0.29 l h-1. The concentrations in tissue reached 27.2 +/- 6 micrograms g-1 in righ epididymis, and 25.4 +/- 6.2 micrograms g-1 in left epididymis. The tissue-versus-serum concentration ratios ranged from 0.175 to 0.545 (mean value, 0.295 +/- 0.099). The concentrations in serum and tissue observed in this st...Continue Reading

References

Dec 1, 1985·Drug Intelligence & Clinical Pharmacy·M C Nahata, W J Barson
Jan 1, 1984·Chemotherapy·D Adam, K G Naber
Nov 1, 1981·Antimicrobial Agents and Chemotherapy·I H PatelS A Kaplan
Jan 1, 1982·The Journal of Antimicrobial Chemotherapy·C D FindlayR Wise
Jan 1, 1982·European Journal of Clinical Pharmacology·P J McNamaraW H Ziegler
Oct 1, 1983·European Journal of Clinical Microbiology·W M Scheld
Jan 1, 1984·Clinical Pharmacology and Therapeutics·J R LudererD W Schneck
Dec 1, 1980·Antimicrobial Agents and Chemotherapy·P AngehrnR L Then
Mar 1, 1981·Antimicrobial Agents and Chemotherapy·H C NeuK P Fu
May 1, 1981·Clinical Pharmacology and Therapeutics·K StoeckelW H Ziegler
Jan 1, 1981·Chemotherapy
Jan 1, 1981·Chemotherapy·I H PatelJ Spicehandler
Aug 1, 1980·Antimicrobial Agents and Chemotherapy·M SeddonR Livingston

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Citations

Apr 24, 2004·Antimicrobial Agents and Chemotherapy·Markus MüllerHartmut Derendorf
May 12, 2007·Journal of the American Geriatrics Society·Joseph A PaladinoJerome J Schentag
May 21, 2005·The American Journal of Geriatric Pharmacotherapy·Barry J Cusack
Feb 17, 2018·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Laura RyanMaeve Doyle

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