PMID: 9003817Jan 1, 1997Paper

Ceftriaxone versus cefazolin in peripheral arterial operations: a randomized, prospective trial

Southern Medical Journal
C B RossT E Peek

Abstract

Serious morbidity and mortality are associated with postoperative wound infections in peripheral vascular surgery. The use of prophylactic antibiotics is considered the standard of care, with attention focused on the most efficacious agent. A prospective, randomized study was conducted to evaluate the efficacy of ceftriaxone versus cefazolin in prevention of postoperative wound infections in a group of patients who had peripheral arterial operations between October 1991 and February 1993. Patient characteristics associated with an increased risk of postoperative wound infection were evaluated. Prophylaxis was provided for 105 operations with cefazolin and 103 operations with ceftriaxone. The overall wound infection rate was 3.85%. Six operations (5.7%) in the cefazolin group were complicated by wound infection versus 2 operations (1.9%) in the ceftriaxone group. Diabetes (6 infections/64 operations; infection rate, 9%) and a personal history of previous aortocoronary bypass (5 infections/49 operations; infection rate, 10%) were characteristics associated with an increased chance for postoperative wound infection. Ceftriaxone is therapeutically equivalent to cefazolin in the prevention of postoperative wound infections in periph...Continue Reading

Citations

Jul 20, 1999·The Surgical Clinics of North America·M M Iafrati
Mar 7, 2013·Surgical Infections·Dale W BratzlerUNKNOWN Society for Healthcare Epidemiology of America (SHEA)
May 23, 2007·Clinical Drug Investigation·Silvano EspositoPaola Venturino
Apr 5, 2002·Plastic and Reconstructive Surgery·John A PerrottiJames E Zins
Jul 21, 2006·The Cochrane Database of Systematic Reviews·A StewartJ J Earnshaw
Feb 22, 2012·Circulation·Alan T HirschUNKNOWN Council on Epidemiology and Prevention
Aug 25, 2001·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·J D ScottJ J Schentag
Oct 8, 2009·Therapeutic Drug Monitoring·Christopher J PayneAlexander R Binning
Jan 19, 2013·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Dale W BratzlerUNKNOWN Society for Healthcare Epidemiology of America

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