Cefuroxime prophylaxis is effective in noninstrumented spine surgery: a double-blind, placebo-controlled study

Spine
Christiane PetignatGiorgio Zanetti

Abstract

Double-blind, placebo-controlled randomized clinical trial. To assess the efficacy of 1 preoperative 1.5 g dose of cefuroxime in preventing surgical site infection after surgery for herniated disc. Antibiotic prophylaxis was only tested in nonconclusive trials in this setting. The study was conducted in 2 university hospitals in Switzerland. Patients were assessed for occurrence of surgical site infection (defined by the criteria of the Centers for Diseases Control and Prevention), other infections, or adverse events up to 6 months after surgery. Outcome measures were compared in a univariate, per-protocol analysis. Baseline characteristics were similar in patients allocated to cefuroxime (n = 613) or placebo (n = 624). Eight (1.3%) patients in the cefuroxime group and 18 patients (2.8%) in the placebo group developed a surgical site infection (P = 0.073). A diagnosis of spondylodiscitis or epidural abscess was made in 9 patients in the placebo group, but none in the cefuroxime group (P < 0.01), which corresponded to a number necessary to treat of 69 patients to prevent one of these infections. There were no significant adverse events attributed to either cefuroxime or placebo. A single, preoperative dose of cefuroxime signific...Continue Reading

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Citations

Mar 7, 2013·Surgical Infections·Dale W BratzlerUNKNOWN Society for Healthcare Epidemiology of America (SHEA)
Dec 19, 2012·Surgical Neurology International·Nancy E Epstein
Aug 31, 2013·The Spine Journal : Official Journal of the North American Spine Society·William O ShafferUNKNOWN North American Spine Society
Nov 20, 2012·Orthopaedics & Traumatology, Surgery & Research : OTSR·S WolffG Riouallon
May 20, 2014·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Nathan EvaniewMichelle Ghert
Jun 9, 2016·Revista Brasileira De Ortopedia·Charbel Jacob JúniorJosé Lucas Batista Júnior
Dec 21, 2019·The Journal of Pharmacy and Pharmacology·Ulrich GergsJoachim Neumann
Mar 14, 2016·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Vijay H D KamathKenneth Man Chee Cheung
Feb 9, 2021·International Journal of Clinical Pharmacy·Weiwei ZhangYongfang Hu
Oct 21, 2020·The Spine Journal : Official Journal of the North American Spine Society·Marco D BurkhardMazda Farshad
Jun 30, 2021·Scientific Reports·Thorsten JentzschMazda Farshad
Jan 19, 2013·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Dale W BratzlerUNKNOWN Society for Healthcare Epidemiology of America

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