Cefuroxime selective electrodes for batch and FIA determinations in pharmaceutical preparations

Journal of Pharmaceutical and Biomedical Analysis
J L LimaM G Sales

Abstract

Different cefuroxime selective electrodes, without internal reference solution and comprising PVC membranes, were constructed and evaluated. Membranes were prepared with cefuroxime tetraoctylammonium (A) or cefuroxime bis(triphenylphosphoranylidene)ammonium (B) as ion-exchanger, 2-nitrophenyl octyl ether (X) or bis(2-ethylhexyl)sebacate (Y) as plasticizing mediator solvent and 4-tert-otcylphenol (TOP) as additive. From the comparative evaluation of the described electrodes, membranes comprising 2-nitrophenyl octyl ether, cefuroxime tetraoctylammonium and 4-tert-otcylphenol presented better working characteristics. For these electrodes (type XA-TOP), with a lifetime > 5 months, a lower limit of linear range of 2.8 x 10(-4) M, a practical detection limit of 1.3 x 10(-4) M, a reproducibility of approximately +/-0.6 mV day(-1) and a slope of -50.4 mV decade(-1), under H3PO4/NaH2PO4 solutions (pH 3.5; I =0.1 M), were found. The presence of the additive on the membranes was of crucial importance for the electrodes good characteristics. Interference from sulphate, chloride, nitrate, iodide, cefaclor, cefadroxil, cefazolin and cephradine, on the electrodes behaviour was evaluated. Only a slight interference from nitrate and iodide was ...Continue Reading

References

Jan 1, 1991·Journal of Pharmaceutical and Biomedical Analysis·J L LimaA M Silva
Jan 1, 1989·Journal of Pharmaceutical and Biomedical Analysis·K Vytras
Jan 1, 1989·Journal of Pharmaceutical and Biomedical Analysis·J L LimaJ G Raurich
Dec 1, 1982·The Analyst·P A CoomberJ D Woodford
Jul 1, 1994·Journal of Pharmaceutical and Biomedical Analysis·J A MurilloL F García
Jan 1, 1988·Journal of Pharmaceutical and Biomedical Analysis·L CampanellaR Sbrilli
Jan 1, 1988·Journal of Pharmaceutical and Biomedical Analysis·L CampanellaM Tomassetti

Citations

Dec 14, 2011·Journal of Fluorescence·Abdalla A ElbashirHassan Y Aboul-Enein
Sep 2, 1999·Pharmaceutical Science & Technology Today·A V Kabanov
Jan 25, 2013·Luminescence : the Journal of Biological and Chemical Luminescence·Abdalla A ElbashirHassan Y Aboul-Enein
Sep 20, 2012·Luminescence : the Journal of Biological and Chemical Luminescence·Shazalia M Ali AhmedHassan Y Aboul-Enein
Aug 11, 2007·Journal of Pharmaceutical and Biomedical Analysis·Salwa R El-ShabouryAzza H Rageh

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