Celastrol Ameliorates EAE Induction by Suppressing Pathogenic T Cell Responses in the Peripheral and Central Nervous Systems.

Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology
Ying WangDeng-Hai Zhang

Abstract

Multiple sclerosis (MS) is the prototypical inflammatory demyelinating disease of the central nervous system (CNS), and MS results in physical and cognitive impairments, such as fatigue, pain, depression and bladder dysfunction. Though many therapies for MS have been developed, the safety profile and effectiveness of these therapies still need to be defined. Thus, new therapies for MS must be explored. Celastrol, a quinonemethide triterpene, is a pharmacologically active compound present in Thunder God Vine root extracts used to treat inflammatory and autoimmune diseases. Molecular studies have identified several molecular targets, which are mostly centered on the inhibition of IKK-NF-κB signaling. The animal model of experimental autoimmune encephalomyelitis (EAE) has been widely used in MS studies; thus, we tried to explore the role of celastrol in EAE development in this study. We demonstrated that the intraperitoneal injection of celastrol significantly attenuated EAE disease. Th17 cell responses in the peripheral lymph nodes in EAE mice were also inhibited by celastrol. We determined that celastroldownregulated cytokine production in bone-marrow derived dendritic cells (BMDCs). Accordingly, T cells that were co-cultured wi...Continue Reading

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Citations

Jul 14, 2016·Pathogens and Disease·Shivaprasad H VenkateshaKamal D Moudgil
May 17, 2019·The American Journal of Chinese Medicine·Jianheng Li, Jijun Hao
Jun 22, 2019·Bioscience Reports·Xiao-Ling LiMan-Xia Wang
Dec 7, 2016·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Guangkui YanJingdong Zhang
Jul 18, 2018·International Journal of Molecular Medicine·Li-Ping HanLi-Ming Chen
Nov 7, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Stefania SchiavoneMaria Grazia Morgese
Jul 1, 2017·Frontiers in Medicine·Rita CascãoLuis F Moita
Mar 2, 2019·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Shivaprasad H Venkatesha, Kamal D Moudgil
Aug 4, 2019·Neurochemistry International·Leila MohtashamiBehjat Javadi
Apr 18, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xue BaiYu-Ping Tang
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Stefania SchiavoneLuigia Trabace

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