Abstract
Celastrol pretreatment has been shown to protect against myocardial ischemia/reperfusion (I/R) injury, but the underlying mechanism is poorly understood. This study aimed to investigate the cardioprotective effects of celastrol pretreatment on I/R injury and to further explore whether its mechanism of action was associated with the inhibition of high mobility group box 1 protein (HMGB1) expression via the phosphoinositide 3-kinase (PI3K)/Akt pathway. In a fixed-dose study, hematoxylin and eosin staining and myocardial enzyme measurements were used to determine the optimal dose of celastrol that elicited the best cardioprotective effects against I/R injury. Furthermore, rats were pretreated with 4 mg/kg celastrol, and infarct size and the levels of myocardial enzymes, apoptosis, inflammatory and oxidative indices, and HMGB1 and p-Akt expression were measured. Our results indicated that celastrol dose-dependently attenuated histopathological changes and the elevation in myocardial enzymes induced by I/R. Moreover, the celastrol pretreatment (4 mg/kg) not only significantly decreased infarct size as well as myocardial enzyme levels but also inhibited myocardial apoptosis, inflammatory response and oxidative stress. Additionally, c...Continue Reading
Citations
Jan 25, 2019·Cardiovascular Drugs and Therapy·Jingyi ChenXianyu Wang
Aug 16, 2019·Drug and Chemical Toxicology·Ramin RezaeeMahmoud Hashemzaei
Aug 23, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Hanyu ShiHaiqing Gao
Apr 21, 2020·The Journal of Gene Medicine·Liping MaJianhua Zhu
Dec 20, 2019·Naunyn-Schmiedeberg's Archives of Pharmacology·Hanqing LiuDanping Xu
Feb 13, 2020·Pharmacological Reports : PR·Vipin Kumar VermaDharamvir Singh Arya
Apr 20, 2019·Frontiers in Cellular Neuroscience·Yingze YeLijuan Gu
Aug 7, 2019·International Journal of Molecular Sciences·Gur P KaushalLuis A Juncos
Oct 12, 2018·Cellular and Molecular Life Sciences : CMLS·Angela RaucciMaurizio C Capogrossi
Apr 27, 2020·British Journal of Pharmacology·Shant Der SarkissianNicolas Noiseux
Oct 6, 2020·Pharmacological Reports : PR·Tarapati RanaSimona Bungau
Feb 19, 2021·Frontiers in Pharmacology·Ruiying WangXiaobo Sun
Oct 12, 2020·Pharmacology & Therapeutics·Chunhui ZhaoLuqi Huang
Dec 12, 2018·Pharmacology & Therapeutics·Laura PellegriniFederica Limana
Jun 17, 2021·Experimental and Therapeutic Medicine·Fengwei LiNeng Wang
Aug 11, 2021·Journal of Neuroinflammation·Dan-Dan LiuJigang Wang