PMID: 11315375Apr 24, 2001Paper

Celecoxib and rofecoxib. The role of COX-2 inhibitors in dental practice

The Journal of the American Dental Association
P A Moore, E V Hersh

Abstract

In recent years, dental practitioners have relied on ibuprofen and other nonsteroidal anti-inflammatory drugs, or NSAIDs--such as naproxen, diflunisal and ketoprofen--to manage acute and chronic orofacial pain. Two NSAIDs that recently came on the market, celecoxib and rofecoxib, have been developed to limit the adverse effects seen after chronic use of NSAIDs. The authors have summarized all available publications describing the human pharmacokinetics, clinical pharmacology and known adverse effects of these new specific cyclooxygenase-2, or COX-2, inhibitors. Although peripherally acting analgesics are remarkably effective, chronic administration of nonselective COX inhibitors has been associated with gastrointestinal ulceration and prolonged bleeding. The authors present the distinctive mechanism of action for these new COX-2 inhibitors, compare their relative anti-inflammatory and analgesic properties and describe their safety profile. They also summarize indications, contraindications and dosing recommendations. Celecoxib and rofecoxib are valuable dental therapeutic agents for the management of inflammatory joint disorders and associated chronic orofacial pain. Additionally, rofecoxib, with its more rapid onset, may be us...Continue Reading

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Citations

Nov 10, 2004·Oral Diseases·J V BagánC Scully
Apr 25, 2007·Journal of Dental Research·T C B SchützS Tufik
Aug 9, 2003·The Journal of Pharmacy and Pharmacology·Naveen AhujaBhupinder Singh
Oct 5, 2006·Current Opinion in Anaesthesiology·T Samad, S Abdi
Aug 21, 2014·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Berrin IşikAlparslan Turan
Jan 25, 2002·Annual Review of Pharmacology and Toxicology·Camilla I Svensson, Tony L Yaksh
Aug 9, 2005·Current Medical Research and Opinion·Elliot V HershPaul A Moore
Jun 29, 2011·Drug Development and Industrial Pharmacy·Ehab A FouadIbrahim A Alsarra
Sep 1, 2006·AAPS PharmSciTech·Kora Pattabhi Ramaiah Chowdary, Sekuboyina Vijaya Srinivas
Dec 20, 2020·Biomolecules·Hunain AliFarzana Shaheen
Oct 10, 2006·AAPS PharmSciTech·Kora Pattabhi Ramaiah Chowdary, Sekuboyina Vijaya Srinivas
Mar 17, 2004·Toxicon : Official Journal of the International Society on Toxinology·C F P TeixeiraY Cury

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