Celecoxib Does Not Protect against Fibrosis and Inflammation in a Carbon Tetrachloride-Induced Model of Liver Injury

Molecular Pharmacology
Todd R HarrisBruce D Hammock

Abstract

The cyclooxygenase-2 (COX-2) selective inhibitor celecoxib is widely used in the treatment of pain and inflammation. Celecoxib has been explored as a possible treatment of liver fibrosis with contradictory results, depending on the model. The present study reports the effect of celecoxib in a 5-week carbon tetrachloride (CCl4)-induced liver fibrosis mouse model. Celecoxib alone and in combination with inhibitors of the enzyme-soluble epoxide hydrolase (sEH), as well as a dual inhibitor that targets both COX-2 and sEH, were administered via osmotic minipump to mice receiving intraperitoneal injections of CCl4 Collagen deposition was elevated in the mice treated with both celecoxib and CCl4 compared with the control or CCl4-only groups, as assessed by trichrome staining. Histopathology revealed more extensive fibrosis and cell death in the animals treated with both celecoxib and CCl4 compared with all other experimental groups. Although some markers of fibrosis, such as matrix metalloprotease, were unchanged or lowered in the animals treated with both celecoxib and CCl4, overall, hepatic fibrosis was more severe in this group. Cotreatment with celecoxib and an inhibitor of sEH or treatment with a dual inhibitor of COX-2 and sEH d...Continue Reading

References

Jun 1, 1996·Clinical Biochemistry·G K Reddy, C S Enwemeka
Dec 18, 2001·Chemical Research in Toxicology·T P ReillyL R Pohl
May 7, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anna PlanagumàJoan Rodés
Oct 20, 2005·Cancer Science·Hitoshi NakagamaMasako Ochiai
Jan 20, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Alex Yui HuiJoseph Jao Yiu Sung
Sep 5, 2006·Proceedings of the National Academy of Sciences of the United States of America·Kara R SchmelzerBruce D Hammock
Nov 14, 2007·European Journal of Clinical Pharmacology·Shaojun Shi, Ulrich Klotz
Apr 26, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Jun YuJoseph J Y Sung
Apr 23, 2010·Biological & Pharmaceutical Bulletin·Yukiko WashinoShosuke Kojo
Jun 8, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·Enrique ChávezPablo Muriel
Oct 2, 2012·Annual Review of Pharmacology and Toxicology·Christophe Morisseau, Bruce D Hammock
Mar 16, 2013·Proceedings of the National Academy of Sciences of the United States of America·Padmini SirishNipavan Chiamvimonvat
Nov 28, 2013·Fibrogenesis & Tissue Repair·Christian LiedtkeRalf Weiskirchen
Feb 26, 2014·Nature Reviews. Immunology·Antonella PellicoroJonathan A Fallowfield
Jun 10, 2014·Journal of Gastroenterology and Hepatology·Shi-Lei WenCheng-Wei Tang
Jul 16, 2014·Proceedings of the National Academy of Sciences of the United States of America·Guodong ZhangBruce D Hammock
Aug 29, 2014·American Journal of Physiology. Renal Physiology·Jinu KimBabu J Padanilam
Nov 15, 2014·Current Pathobiology Reports·Allyson K MartínezShannon S Glaser
Jun 16, 2015·Prostaglandins & Other Lipid Mediators·David SacerdotiMassimo Bolognesi
Mar 19, 2016·The Journal of Pharmacology and Experimental Therapeutics·Sumanta Kumar GoswamiBruce D Hammock
Jul 20, 2016·Prostaglandins & Other Lipid Mediators·Md Abdul Hye KhanJohn D Imig
Oct 21, 2016·Expert Opinion on Drug Safety·Fernando BessoneRaúl J Andrade
Oct 13, 2016·The Journal of Nutritional Biochemistry·Todd R HarrisBruce D Hammock

❮ Previous
Next ❯

Citations

Sep 7, 2020·Pharmacology & Therapeutics·Anna FishbeinDipak Panigrahy
Mar 29, 2021·Acta Tropica·Iman Fathy Abou-El-NagaEman Ibrahim Ibrahim
Oct 3, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Semih BaghakiErsin Yavuz
Aug 20, 2021·Biochemical Pharmacology·María de Luján Alvarez, Florencia Lorenzetti
Sep 30, 2021·Experimental and Therapeutic Medicine·Shi FengShi-Lei Wen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Reumatizam
D Babić-Naglić
Deutsche medizinische Wochenschrift
R FuxC H Gleiter
Journal of the Royal Society of Medicine
Raymond Cheung, Simon Lowry
Revista de medicina de la Universidad de Navarra
E CaballeroJ Honorato
Clinical Journal of Oncology Nursing
M E O'Rourke
© 2022 Meta ULC. All rights reserved