Celecoxib for osteoarthritis

The Cochrane Database of Systematic Reviews
Livia PuljakPeter Tugwell

Abstract

Osteoarthritis (OA) is the most common form of arthritis and is caused by degeneration of the joint cartilage and growth of new bone, cartilage and connective tissue. It is often associated with major disability and impaired quality of life. There is currently no consensus on the best treatment to improve OA symptoms. Celecoxib is a selective non-steroidal anti-inflammatory drug (NSAID). To assess the clinical benefits (pain, function, quality of life) and safety (withdrawals due to adverse effects, serious adverse effects, overall discontinuation rates) of celecoxib in osteoarthritis (OA). We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase and clinical trials registers up to April 11, 2017, as well as reference and citation lists of included studies. Pharmaceutical companies and authors of published articles were contacted. We included published studies (full reports in a peer reviewed journal) of prospective randomized controlled trials (RCTs) that compared oral celecoxib versus no intervention, placebo or another traditional NSAID (tNSAID) in participants with clinically- or radiologically-confirmed primary OA of the knee or hip, or both knee and hip. Two authors independently performed...Continue Reading

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Citations

Jul 4, 2018·International Journal of Molecular Sciences·Elena DamiaJose Maria Carrillo
Jun 20, 2019·Journal of Bone and Mineral Metabolism·Wenshan ShanZongsheng Yin
Feb 26, 2019·The Cochrane Database of Systematic Reviews·Amanda O LeopoldinoManuela L Ferreira
Mar 13, 2021·Biomedical Materials·Xueli MeiElizabeth R Gillies
Jun 12, 2021·International Journal for Equity in Health·Elizabeth Houlding-BraunbergerPeter Tugwell
Oct 12, 2021·Frontiers in Medicine·Thit Mynster KronborgNina Kimer

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