PMID: 12376474Oct 12, 2002Paper

Celecoxib reduces pulmonary inflammation but not lung tumorigenesis in mice

Carcinogenesis
Lori R KisleyAlvin M Malkinson

Abstract

Cyclooxygenase (COX) enzyme expression is elevated in human and rodent lung tumors, and non-steroidal anti-inflammatory drugs (NSAIDs) such as indomethacin reduce lung tumor formation in mice. These observations, along with the well-characterized protection that NSAID treatment engenders for colon cancer, have prompted clinical trials testing whether celecoxib, a COX-2-specific inhibitor, can prevent lung cancer development in populations at high risk. Protection by celecoxib in murine models of pulmonary inflammation and lung tumorigenesis has not yet been evaluated, however, and we now report such studies. Chronic administration of butylated hydroxytoluene (BHT) to mice stimulates pulmonary inflammation characterized by vascular leakage and macrophage infiltration into the air spaces, increased PGE2 production, and translocation of 5-lipoxygenase (5-LO) from the cytosol to the particulate fraction. Dietary celecoxib limited macrophage infiltration, abrogated PGE2 production and reduced particulate 5-LO content. Celecoxib and aspirin were ineffective at preventing lung tumorigenesis in a two-stage carcinogenesis protocol in which 3-methylcholanthrene administration is followed by chronic BHT. Celecoxib also did not reduce the ...Continue Reading

Citations

Jun 25, 2009·Nature Reviews. Cancer·Stephen S HechtDorothy K Hatsukami
May 22, 2013·Nature Reviews. Clinical Oncology·Robert L Keith, York E Miller
Jun 2, 2005·Current Opinion in Pulmonary Medicine·Robert L Keith, York E Miller
Mar 16, 2005·Experimental Lung Research·Alvin M Malkinson
Jan 5, 2016·Trends in Pharmacological Sciences·Silvio De FloraRoumen Balansky
Jun 2, 2004·International Journal of Cancer. Journal International Du Cancer·Guillermo D PeluffoSlobodanka M Klein
Oct 6, 2007·Chest·Jhanelle GrayUNKNOWN American College of Chest Physicians
Jul 17, 2012·Environmental Toxicology and Pharmacology·Manuraj Pandey, Krishna P Gupta
Nov 5, 2003·Clinical Lung Cancer·Santiago Ballaz, James L Mulshine
Oct 22, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J A GuariscoR A Coulombe
Oct 24, 2007·The Journal of Surgical Research·Reid C VegelerC Max Schmidt
Jan 24, 2009·Biochemical Pharmacology·Paulo CastroVera Lucia G Koatz
Dec 13, 2005·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·L A FaineE L B Novelli
Jun 9, 2005·The Journal of Thoracic and Cardiovascular Surgery·Eric M SieversRoss M Bremner
Jul 15, 2016·BMC Complementary and Alternative Medicine·Jung Up ParkYoung Ran Kim
Feb 4, 2010·Biochimica Et Biophysica Acta·Mary-Clare CathcartGraham P Pidgeon
Aug 20, 2016·Molecular Pharmaceutics·Muhammad SarfrazRaimar Löbenberg
May 12, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Fred R Hirsch, Scott M Lippman
Jan 30, 2009·Veterinary Pathology·A K Bauer, E A Rondini
Sep 10, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Alison K BauerSteven R Kleeberger
Oct 30, 2003·British Journal of Cancer·C N HolickE Giovannucci
Mar 16, 2019·Carcinogenesis·Ingrid ElisiaGerald Krystal
Sep 29, 2018·Oncotarget·Alberto IzzottiSilvio De Flora
Mar 16, 2005·Experimental Lung Research·Anna Maciag, Lucy M Anderson
Mar 20, 2020·BMC Complementary Medicine and Therapies·Hai-Ning WeeHwee-Ling Koh
May 18, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Gu Seob RohJong Deog Lee
Oct 27, 2016·Cancer Prevention Research·Luai Al Rabadi, Raymond Bergan
Apr 5, 2005·Cancer Research·Jillian N M IlsleyDaniel W Rosenberg
Dec 29, 2020·Frontiers in Pharmacology·Amber M JohnsonRaphael A Nemenoff

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.