Celiac autoimmunity in autoimmune thyroid disease is highly prevalent with a questionable impact

Indian Journal of Endocrinology and Metabolism
Bharat Rakeshkumar SharmaPratibha S Pawal

Abstract

The prevalence of autoimmune thyroid disease (AITD) is 10-12% in the general population worldwide. Among various disorders co-existing with AITD, the concomitance of celiac disease (CD) with AITD results in poor absorption of thyroid medications and results in higher doses of the same. Institution of gluten-free diet (GFD) in this cohort helps reduce medication doses. To screen patients with AITD for the presence of celiac autoimmunity (CA). A total of 280 consecutive patients with AITD attending the thyroid Out-patient Department of a tertiary care hospital were screened for the presence of tissue transglutaminase antibodies (immunoglobulin A tissue transglutaminase). Those with a positive titer (but < 10 times the upper limit of normal) underwent upper gastrointestinal endoscopy and duodenal mucosal biopsy for the diagnosis of CD, followed by institution of GFD in confirmed cases. Of a total of 280 (182 females and 98 males) patients with AITD screened, 24 (8.6%) turned out to be positive for CA. Of 24 (8.6%), 15 (8.24%) females and 9 (9.18%) males were positive for CA. There was no statistically significant difference in the thyroxine doses required for normalization of thyroid function and the weight of the patients in CA p...Continue Reading

References

Oct 1, 1990·Archives of Disease in Childhood·M MäkiJ K Visakorpi
Feb 1, 1994·European Journal of Endocrinology·P CollinA Pasternack
Jan 1, 1999·European Journal of Gastroenterology & Hepatology·C Sategna-GuidettiC Brossa
Aug 17, 1999·Sexually Transmitted Infections·N MeljanacC C Zouboulis
Aug 26, 1999·Hormone Research·R ValentinoR Troncone
Nov 20, 2001·The Journal of Pediatrics·D LarizzaM Martinetti
Aug 14, 2003·Journal of Molecular Endocrinology·D A Chistiakov, R I Turakulov
Jan 20, 2005·European Journal of Human Genetics : EJHG·Karen A HuntDavid A van Heel
Jul 10, 2008·The Journal of Clinical Endocrinology and Metabolism·Peter ElfströmJonas F Ludvigsson
Mar 10, 2010·Nature Reviews. Gastroenterology & Hepatology·Greetje J TackChris J J Mulder
Sep 7, 2011·British Medical Bulletin·Mark P J Vanderpump

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Citations

Aug 4, 2016·Clinical Medicine Insights. Gastroenterology·Maria CappelloAnna Licata

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
biopsy

Software Mentioned

Statistical Package for Social Sciences

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Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Autoimmune Thyroiditis

Autoimmune thyroiditis is an inflammatory disease of thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. Discover the latest research on autoimmune thyroiditis here.

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