Celiac Disease and Liver Disorders: From Putative Pathogenesis to Clinical Implications

Nutrients
Iva HoffmanováHelena Tlaskalová-Hogenová

Abstract

Immunologically mediated liver diseases belong to the common extraintestinal manifestations of celiac disease. We have reviewed the current literature that addresses the association between celiac disease and liver disorders. We searched relevant articles on MEDLINE/PubMed up to 15 June 2018. The objective of the article is to provide a comprehensive and up-to-date review on the latest hypotheses explaining the pathogenetic relationship between celiac disease and liver injury. Besides the involvement of gut⁻liver axis, tissue transglutaminase antibodies, and impairment of intestinal barrier, we integrate the latest achievements made in elucidation of the role of gut microbiota in celiac disease and liver disorders, that has not yet been sufficiently discussed in the literature in this context. The further objective is to provide a complete clinical overview on the types of liver diseases frequently found in celiac disease. In conclusion, the review highlights the clinical implication, recommend a rational approach for managing elevated transaminases in celiac patients, and underscore the importance of screening for celiac disease in patients with associated liver disease.

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Citations

Oct 9, 2019·Nutrients·Richa Chibbar, Levinus A Dieleman
Sep 13, 2019·Journal of Clinical Gastroenterology·Amelie TherrienJocelyn A Silvester
Aug 24, 2018·Cellular and Molecular Life Sciences : CMLS·Stefania MartuccielloIvana Caputo
Apr 2, 2020·Nutrients·Marco ValvanoGiovanni Latella
Oct 5, 2019·Nutrients·Iva HoffmanováHelena Tlaskalová-Hogenová
Feb 13, 2021·Journal of Hepatology·Roman LiebeVerena Keitel
Apr 4, 2021·Microorganisms·Daniel SánchezHelena Tlaskalová-Hogenová
Apr 22, 2021·International Journal of Immunopathology and Pharmacology·Taoufik Ben Houmich, Brahim Admou
Jun 18, 2021·Clinical Liver Disease·Muhammad Amir, Samir M Parekh
Sep 30, 2021·European Journal of Pediatrics·Asaf RegevAchiya Z Amir
Oct 9, 2021·Scientific Reports·Jessica VossPavel Strnad
Nov 3, 2021·Journal of Agricultural and Food Chemistry·Maria Rosa Pérez-GregorioVictor de Freitas

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Methods Mentioned

BETA
biopsy
urine collection
biopsies
ELISA

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