Celiac Disease and Wheat Allergy: A Growing Association?

International Archives of Allergy and Immunology
Sarah MicozziLydia Zapatero

Abstract

Celiac disease and wheat allergy (WA) are infrequent diseases in the general population, and a combination of the 2 is particularly rare. Celiac disease occurs in around 1% of the general population and WA in around 1% of all children. We report 2 patients with celiac disease and a gluten-free diet who developed WA consistent in anaphylaxis and an eyelid angioedema, respectively, through accidental wheat exposure. A serum study and an intestinal biopsy confirmed celiac disease. Both patients were studied with a skin prick test and serum-specific IgE, with a diagnosis of WA. In patients with celiac disease, the trace amounts of cereals present in gluten-free food could act as a sensitization factor, and probably patients with persistent symptoms (despite a gluten-free diet) are experiencing WA symptoms rather than celiac disease symptoms. The number of patients diagnosed with celiac disease has increased in the recent decades: the association between celiac disease and WA, exceedingly rare to date, could increase as well, prompting special attention to the possibility of inadvertent intake of cereals.

References

Oct 1, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A S Tatham, P R Shewry
Feb 22, 2012·Gut·Jonas F LudvigssonCarolina Ciacci
Jul 22, 2014·Alimentary Pharmacology & Therapeutics·A J LucendoJ M Tenias
Jan 1, 2014·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Tiffany WongEdmond S Chan
Jun 26, 2015·World Journal of Gastroenterology : WJG·Luca ElliMaria Teresa Bardella
Sep 12, 2015·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·M F Martín-MuñozS Quirce

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Citations

Apr 20, 2019·Frontiers in Immunology·Isabel J Skypala

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