Celiac Disease Autoimmunity

Archivum Immunologiae Et Therapiae Experimentalis
Miguel Ángel López CasadoMaria Isabel Torres

Abstract

Celiac disease is an autoimmune condition triggered by the ingestion of gluten, the protein fraction of wheat, barley and rye. It is not simply an intestinal disease; it is multifactorial caused by many different genetic factors acting together with non-genetic causes. Similar to other autoimmune diseases, celiac disease is a polygenic disorder for which the major histocompatibility complex locus is the most important genetic factor, and is the result of an immune response to self-antigens leading to tissue destruction and the autoantibodies production. Celiac disease exemplifies how an illness can have autoimmune-like features having to be driven by exogenous antigen and how can be reasonably considered as a model of organ-specific autoimmunity.

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Citations

Jun 28, 2019·Cellular & Molecular Immunology·Candelaria Ponce de LeónMaría Isabel Torres
Apr 4, 2021·International Journal of Molecular Sciences·Johannes WolfHans Binder
May 1, 2021·International Journal of Molecular Sciences·Valerio FulciClaudia Carissimi
Jul 6, 2021·Frontiers in Immunology·Candelaria Ponce de LeónMaría Isabel Torres
Jul 9, 2021·Curēus·Hind A AlqahtaniAbdulhadi M Sumaili
Sep 14, 2021·Physiology·Shani Talia Gal-Oz, Tal Shay

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Methods Mentioned

BETA
biopsy

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