Abstract
Celiac disease, an autoimmune enteropathy triggered by exposure to gluten, is not uncommon in South Jordan. However, its prevalence is underestimated due to lack of physician awareness of the diversity of disease presentation. The clinical spectrum includes classic gastrointestinal manifestations, as well as rickets, iron-deficiency anemia, short stature, elevated liver enzymes, and edema. Our goal was to evaluate celiac disease presentation in clinically diagnosed children. Retrospective study included all children diagnosed with celiac disease between September 2009 and September 2015. Hospital charts were reviewed. Demographic data, clinical characteristics, and follow-up were recorded. Thirty-five children were diagnosed with celiac disease during the study period. Mean age±standard deviation was 6.7±3.8 years (range, 2.0-14 years). There were 17 (48.6%) female patients. The average duration between onset of symptoms and diagnosis was 16.3±18.7 months. Fifteen (42.9%) patients presented with classic malabsorption symptoms, whereas 7 (20.0%) patients presented with short stature. Positive tissue transglutaminase antibodies (tTg)-immunoglobulin A (IgA) was seen in 34 (97.1%) patients. The one patient with negative tTg-IgA had...Continue Reading
References
Nov 1, 1996·Journal of Pediatric Gastroenterology and Nutrition·M O RawashdehE Raweily
Apr 1, 2004·Endocrinology and Metabolism Clinics of North America·Marian RewersEdward J Hoffenberg
Dec 31, 2004·Journal of Pediatric Gastroenterology and Nutrition·Ivor D HillUNKNOWN North American Society for Pediatric Gastroenterology, Hepatology and Nutrition
Nov 22, 2007·Journal of Pediatric Gastroenterology and Nutrition·Richard L MonesJoel R Rosh
May 22, 2008·Journal of Pediatric Gastroenterology and Nutrition·Silvana SalardiAlessandro Cicognani
Apr 28, 2009·Lancet·Antonio Di Sabatino, Gino Roberto Corazza
Oct 8, 2009·Journal of Clinical Gastroenterology·Esmeralda CapristoGiovanni Gasbarrini
Oct 14, 2009·World Journal of Gastroenterology : WJG·Santiago VivasLuis Rodrigo
Feb 26, 2010·Italian Journal of Pediatrics·Mohamad K NusierHelge Klungland
Mar 25, 2010·World Journal of Gastroenterology : WJG·Kassem BaradaPeter Green
Dec 27, 2011·Journal of Pediatric Gastroenterology and Nutrition·S HusbyUNKNOWN European Society for Pediatric Gastroenterology, Hepatology, and Nutrition
Feb 22, 2012·Gut·Jonas F LudvigssonCarolina Ciacci
Jan 8, 2014·JAMA Pediatrics·Stefano Guandalini, Asaad Assiri
Sep 30, 2015·The American Journal of Gastroenterology·Prashant SinghGovind K Makharia
Mar 1, 2017·Journal of Gastroenterology and Hepatology·Jessica R Biesiekierski
May 11, 2017·World Journal of Gastroenterology : WJG·Hugh James Freeman