Celiac disease: what's new about it?

Digestive Diseases
Giovanni GasbarriniEsmeralda Capristo

Abstract

In the present review we will try to summarize the clinical and diagnostic features of celiac disease (CD) as well as the new findings on extraintestinal manifestation. CD is an immune-mediated enteropathy caused by a permanent gluten intolerance. In the last years, the diagnosis is becoming more and more frequent because of the recognition of 'new' symptoms and associated extraintestinal manifestations. Classical CD is dominated by symptoms and sequelae of gastrointestinal malabsorption. In the 'atypical forms', the extraintestinal features usually predominate, with few or no gastrointestinal symptoms. Silent CD refers to asymptomatic patients with a positive serologic test and villous atrophy on biopsy. This form is detected by screening of high-risk individuals, or villous atrophy occasionally may be detected by endoscopy and biopsy conducted for another reason. The potential form is diagnosed in groups at risk including relatives of celiac patients, Down syndrome and autoimmune diseases. Latent CD is defined by positive serological tests but not histological changes on biopsy. These individuals are asymptomatic, but later may develop symptoms and/or histological alterations. Recognition of atypical manifestations of CD is v...Continue Reading

Citations

Dec 29, 2011·Irish Journal of Medical Science·A SaleemP O' Regan
Feb 1, 2011·Clinical Reviews in Allergy & Immunology·Orit RozenbergMira Barak
Dec 25, 2012·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Prashant SinghAbdus Sami Bhat
Sep 1, 2008·Case Reports in Gastroenterology·Giuseppe MerraGiovanni Ghirlanda
Oct 12, 2012·Journal of Biomedical Science·Francesca Megiorni, Antonio Pizzuti
Jan 18, 2014·Internal and Emergency Medicine·Giovanni Battista GasbarriniAntonio Gasbarrini
Nov 27, 2009·Postgraduate Medicine·Genji S Terasaki, Kamal S Ajam
Feb 10, 2017·Journal of Magnetic Resonance Imaging : JMRI·Amir Reza RadmardBijan Shahbazkhani
Aug 2, 2014·United European Gastroenterology Journal·Gb Gasbarrini, F Mangiola
Feb 15, 2011·Cellular & Molecular Immunology·Orit RozenbergMira Barak
Feb 24, 2012·Journal of Magnetic Resonance Imaging : JMRI·Ernesto TomeiRichard C Semelka
Jul 12, 2012·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Sandra RathsmanPer Olcén
Mar 25, 2009·International Journal of Immunopathology and Pharmacology·G GasbarriniF Bonvicini

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