Cell adhesion and migration. III. Leukocyte adhesion and transmigration in the liver vasculature

The American Journal of Physiology
H Jaeschke, C W Smith

Abstract

Leukocytes, i.e., neutrophils, monocytes, and lymphocytes, can accumulate in the hepatic vasculature and contribute to the pathophysiology of various liver diseases. Recently, significant progress has been made in the understanding of the basic mechanisms of neutrophil infiltration and cytotoxicity in the liver. However, there are a substantial number of unresolved issues. This article describes the current knowledge and the gaps in our understanding of mechanisms of neutrophil sequestration in sinusoids and venules, adhesion to endothelial cells, and transmigration and adherence to parenchymal cells. From these data, it is clear that assumptions regarding the roles of adhesion molecules in the liver may be misleading if drawn from studies of peripheral vascular beds. Greater insight into these mechanisms is critical for the development of selective therapeutic strategies that attenuate excessive inflammatory responses without compromising the vital host defense.

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Citations

Feb 24, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·R W BrockR F Potter
May 16, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·S Pérez-Del-PulgarJ Rodés
Jan 27, 2006·World Journal of Gastroenterology : WJG·Anatol PanasiukKarol Radomski
Aug 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J J JonesO D Rotstein
Feb 18, 2011·Histochemistry and Cell Biology·Ahmad AmanzadaGiuliano Ramadori
Jun 3, 2011·Journal of Veterinary Emergency and Critical Care·Naglaa Abdel Megid GomaaGerald Fritz Schusser
Feb 23, 2017·World Journal of Gastroenterology : WJG·Yu ShiZu-Hua Gao
Nov 22, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ian N HinesMatthew B Grisham
Nov 14, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·F MoulinR A Roth
Jan 19, 2005·World Journal of Gastroenterology : WJG·Xiang-Nong LiBarry Alexander
Oct 22, 2002·American Journal of Physiology. Cell Physiology·Arup ChakrabortyC Wayne Smith
Jul 23, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ana OteizaKaren Kristine Sørensen
Jul 15, 2003·Clinical Microbiology Reviews·Edwin S Van AmersfoortJohan Kuiper

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