PMID: 15348663Sep 7, 2004Paper

Cell adhesion and proliferation on biomimetic calcium-phosphate coatings produced by a sodium silicate gel methodology

Journal of Materials Science. Materials in Medicine
A L OliveiraR L Reis

Abstract

The present study describes a methodology to produce bioactive coatings on the surface of starch based biodegradable polymers or other polymeric biomaterials. As an alternative to the more typical bioactive glass percursors, a sodium silicate gel is being employed as a nucleating agent, for inducing the formation of a calcium-phosphate (Ca-P) layer. The method has the advantage of being able to coat efficiently both compact materials and porous 3D architectures aimed at being used on tissue replacement applications and as bone tissue engineering scaffolds. This treatment is also very effective in reducing the incubation periods, being possible to observe the formation of an apatite-like layer, only after 6 h of immersion in a simulated body fluid (SBF). The influence of the SBF concentration on the formation of the apatite coating was also studied. The apatite coatings formed under different conditions were analyzed and compared in terms of morphology, chemical composition and structure. After the first days of SBF immersion, the apatite-like films exhibit the typical cauliflower like morphology. With increasing immersion times, these films exhibited a partially amorphous nature and the Ca/P ratios became very closer to the val...Continue Reading

Citations

Feb 26, 2010·Journal of the Royal Society, Interface·Catarina M AlvesJohn A Hunt
Nov 7, 2016·Journal of Biomedical Science·G S SailajaH K Varma
Feb 7, 2007·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·A RingS Langer
Sep 10, 2013·Science and Technology of Advanced Materials·Cijun ShuaiAnjie Min
Aug 2, 2005·Journal of Biomedical Materials Research. Part a·Johanna HolmbomRisto Penttinen
Oct 16, 2008·Journal of Biomaterials Science. Polymer Edition·J V AraujoN M Neves

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