PMID: 9539744May 16, 1998Paper

Cell adhesion and the integrin-linked kinase regulate the LEF-1 and beta-catenin signaling pathways

Proceedings of the National Academy of Sciences of the United States of America
A NovakS Dedhar

Abstract

The integrin-linked kinase (ILK) is an ankyrin repeat containing serine-threonine protein kinase that can interact directly with the cytoplasmic domains of the beta1 and beta3 integrin subunits and whose kinase activity is modulated by cell-extracellular matrix interactions. Overexpression of constitutively active ILK results in loss of cell-cell adhesion, anchorage-independent growth, and tumorigenicity in nude mice. We now show that modest overexpression of ILK in intestinal epithelial cells as well as in mammary epithelial cells results in an invasive phenotype concomitant with a down-regulation of E-cadherin expression, translocation of beta-catenin to the nucleus, formation of a complex between beta-catenin and the high mobility group transcription factor, LEF-1, and transcriptional activation by this LEF-1/beta-catenin complex. We also find that LEF-1 protein expression is rapidly modulated by cell detachment from the extracellular matrix, and that LEF-1 protein levels are constitutively up-regulated at ILK overexpression. These effects are specific for ILK, because transformation by activated H-ras or v-src oncogenes do not result in the activation of LEF-1/beta-catenin. The results demonstrate that the oncogenic propert...Continue Reading

References

Oct 1, 1988·Molecular and Cellular Biology·J FilmusR N Buick
Dec 1, 1994·The Journal of Cell Biology·J HülskenJ Behrens
May 1, 1996·Molecular and Cellular Biology·J PapkoffP Polakis
Oct 1, 1996·Current Opinion in Cell Biology·O HuberR Kemler
Apr 1, 1997·Trends in Genetics : TIG·R T MoonM Torres
May 23, 1997·The Journal of Biological Chemistry·G RadevaS Dedhar

❮ Previous
Next ❯

Citations

Sep 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·M DelcommenneS Dedhar
Aug 26, 1999·Journal of Neurochemistry·T P PalosB D Howard
Mar 1, 2000·Molecular Pathology : MP·J L Jones, R A Walker
Jul 27, 2000·The Journal of Biological Chemistry·V W DingF McCormick
Nov 6, 2001·The Journal of Biological Chemistry·Sotiris N Nikolopoulos, Christopher E Turner
Mar 21, 2002·The Journal of Biological Chemistry·Zhigang WengJackie Papkoff
Mar 28, 2002·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·F PiardL Martin
Mar 21, 2002·Expert Opinion on Therapeutic Targets·Jeremy R Graff
Jun 22, 2002·The Journal of Biological Chemistry·Leslie FischerRocky S Tuan
Jul 5, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·G LiM Herlyn
Nov 20, 2002·Biological Chemistry·Irene von LüttichauMatthias Kretzler
Dec 31, 2002·Physiological Reviews·Hermann PavenstädtMatthias Kretzler
Feb 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Feng Cong, Harold Varmus
Jun 15, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ryan R DriskellJohn F Engelhardt
Sep 24, 2004·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Q Jackie CaoJoan G Jones
Jan 5, 2005·Nature Reviews. Cancer·Gregory HanniganShoukat Dedhar
Mar 19, 2005·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Takayuki YasunagaEisuke Nishida
Jun 9, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Julie R HensJohn J Wysolmerski
Mar 17, 2005·Neuroreport·Shinji TakebayashiJuichi Ito
Nov 1, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Brad J MartinsenJamie L Lohr
Apr 28, 2007·American Journal of Respiratory Cell and Molecular Biology·Hays W J YoungChristopher M Evans
Mar 12, 2008·The Journal of Cell Biology·Hao-Ven WangReinhard Fässler
Aug 5, 2008·Neurochemical Research·Joel Cerna CortésBulmaro Cisneros
Apr 22, 2008·Cell Proliferation·L IkonomouM C Gershengorn
May 10, 2012·Cell Adhesion & Migration·Carolina Epifano, Mirna Perez-Moreno
Aug 12, 2015·Journal of the American Society of Nephrology : JASN·Zhiyong ChenEmmanuelle Plaisier
Sep 30, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Dorota GilPiotr Laidler

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.