Cell adhesion molecules and cancer metastasis

Japanese Journal of Pharmacology
I Saiki

Abstract

The adhesive interaction between tumor cells and host cells or the extracellular matrix plays a crucial role in metastasis formation. Therefore, understanding the mechanism controlling metastasis may assist in the development of antimetastatic therapy. We have used synthetic or recombinant polypeptide analogues containing the Arg-Gly-Asp (RGD) sequence found in the functional domains of fibronectin, such as poly(RGD) or CH-271, to regulate the mechanisms involved in cell adhesion during the metastatic process. Poly(RGD) inhibited experimental lung and liver metastasis effectively when coinjected i.v. with various types of tumors. In a model of spontaneous lung metastasis using the B16-BL6 melanoma, repeated administration of this polypeptide before or after surgical excision of the primary tumor resulted in a significant inhibition of tumor metastasis without affecting the growth of the primary tumor and substantially prolonged the survival time of mice. The mechanism responsible for the inhibition of tumor metastasis by the polypeptides is at least partly associated with the ability to interfere with cellular functions such as adhesiveness, motility and invasiveness in the process of metastasis. Combined treatment of the CH-27...Continue Reading

References

Jul 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·R D RosenbergL Lam
Apr 1, 1975·Experimental Cell Research·S B Oppenheimer
Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·C HessionK McCarthy
May 31, 1991·Biochemical and Biophysical Research Communications·H KumagaiM Ohba
Sep 1, 1991·International Journal of Peptide and Protein Research·J MurataI Azuma
May 1, 1991·Cancer Metastasis Reviews·C W Smith, D C Anderson
Nov 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·D Z ZhuB U Pauli
Dec 1, 1991·The Journal of Cell Biology·M E el-Sabban, B U Pauli
Aug 2, 1990·Nature·T A Springer
Jan 2, 1991·International Journal of Cancer. Journal International Du Cancer·A M AnderssonE Bock
Jan 17, 1991·Nature·T A Springer, L A Lasky
Feb 1, 1991·International Journal of Cancer. Journal International Du Cancer·K TakedaK Kumagai
Apr 1, 1991·The Journal of Cell Biology·U H FrixenW Birchmeier
Apr 1, 1991·International Journal of Cancer. Journal International Du Cancer·M M MareelF M Van Roy
May 1, 1990·Japanese Journal of Cancer Research : Gann·J MurataI Azuma
Nov 15, 1990·International Journal of Cancer. Journal International Du Cancer·S ReberM Zöller
Feb 28, 1986·Cell·E Ruoslahti, M D Pierschbacher
Jan 23, 1987·Science·J Folkman, M Klagsbrun
Aug 1, 1989·International Journal of Biological Macromolecules·J MurataS Tokura
Sep 1, 1989·Japanese Journal of Cancer Research : Gann·J MurataI Azuma
Jan 1, 1985·Advances in Cancer Research·J Folkman
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J P JohnsonG Riethmüller

❮ Previous
Next ❯

Citations

Jan 14, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Eszter SiposMichal Toborek
Aug 27, 1998·Seminars in Oncology Nursing·P J Haylock
Mar 6, 2010·Journal of Cancer Research and Clinical Oncology·Qiong-Fang YuJian-Lin Ren
Jan 14, 2016·Redox Biology·Maneet BhatiaKathryn F Tonissen
Jan 18, 2005·Journal of Biotechnology·Yi-Bing HuangXue-Zhong Zhang
Apr 20, 2006·Journal of Biotechnology·Yi-Bing HuangXue-Zhong Zhang
Nov 1, 2003·Cancer Chemotherapy and Pharmacology·Xian-Ming ZhangQiang Xu
Aug 19, 2014·Archives of Gynecology and Obstetrics·Michał WojciechowskiAndrzej Malinowski
May 2, 2016·Cancer Letters·Zhongyue LuoShengtao Zhou
Nov 11, 2016·Archives of Gynecology and Obstetrics·Michał WojciechowskiAndrzej Malinowski
Aug 17, 1999·Journal of Biomedical Materials Research·J DobkowskiH M Kowalczyńska
Nov 28, 2002·International Journal of Cancer. Journal International Du Cancer·Ho-Hsiang ChenKoichi Furukawa
May 6, 2010·The Journal of Pharmacology and Experimental Therapeutics·Rie SaekiKiyohito Yagi
Aug 24, 2001·International Journal of Cancer. Journal International Du Cancer·H FujitaN Kuzumaki
Jan 30, 2002·Experimental Biology and Medicine·Ye-Guang ChenShao-Yao Ying
Oct 17, 2020·OncoTargets and Therapy·Akitsugu MakinoYuko Kitagawa
Mar 21, 2020·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·Bruce E EllerinJoseph T Martins
Oct 18, 2000·Critical Reviews in Oncology/hematology·O Oudar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.