Cell adhesion molecules in clinical renal transplantation

Transplantation
S V Fuggle, D D Koo

Abstract

Leukocyte adhesion molecules are critically involved at a number of stages in immune and inflammatory responses, and their importance in the response to a renal allograft has been recognized for some years. They are involved in antigen presentation, in the cascade of events leading to extravasation of leukocytes into the allograft, in the subsequent migration of leukocytes through the extracellular matrix, and in the interactions between effector and target cells. Thus the adhesion molecules are highly attractive targets for therapeutic intervention in organ transplantation. Strategies have been explored to exploit the involvement of adhesion molecules in ischemia/reperfusion injury, allograft rejection, and the induction of immunological tolerance. Furthermore, the expression of a number of adhesion molecules is regulated by cytokines, and elevated levels may be detected both in transplant biopsies and as soluble forms measured in serum and urine. It has been proposed that these changes in levels might provide useful information in the diagnosis of allograft rejection and differentiation from other causes of graft dysfunction.

References

Feb 1, 1991·The Journal of Cell Biology·K D PatelT M McIntyre
Feb 1, 1991·Kidney International·M G SuranyiB M Hall
Dec 1, 1989·Kidney International·G A Bishop, B M Hall
Oct 1, 1993·Immunology Today·A J Gearing, W Newman
Mar 1, 1995·The Journal of Cell Biology·R AlonT A Springer
Jun 27, 1995·Transplantation·G AlcaldeM J Novo
May 1, 1995·Kidney International·P A HillR C Atkins
Apr 1, 1993·Clinical and Experimental Immunology·Y LinR M Taylor
Jun 6, 1995·Biochemical and Biophysical Research Communications·H RabbG Ramirez
Jan 27, 1995·Transplantation·T G PetersJ W Blanton
Jan 18, 1994·Proceedings of the National Academy of Sciences of the United States of America·K J KellyJ V Bonventre
Mar 1, 1996·Immunology Today·M A del PozoF Sanchez-Madrid
Apr 1, 1997·Nature Medicine·L BenimetskayaC A Stein
Feb 1, 1997·Transplantation Proceedings·S M StepkowskiF C Bennett

❮ Previous
Next ❯

Citations

Oct 2, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G L BumgardnerC G Orosz
Jan 7, 2004·Biochemical and Biophysical Research Communications·Jae Youl ChoJee H Jung
Mar 20, 1999·Transplantation Proceedings·D Abramowicz, M Wissing
Oct 8, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·A Räisänen-SokolowskiM E Russell
Jun 28, 2003·Trends in Molecular Medicine·Klaus Ley
May 7, 1999·Kidney International·A J McLarenK I Welsh
Feb 14, 2002·Kidney International·Isabel M McMorrowChristian LeGuern
Oct 6, 2000·The New England Journal of Medicine·U H von Andrian, C R Mackay
Oct 19, 2005·The Journal of Experimental Medicine·Hongsi JiangYoshinori Fukui
Mar 25, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·G KrishnaswamyD S Chi
Feb 18, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ilkka HelanteräIrmeli Lautenschlager
Mar 18, 2003·Transplantation·Marie-Cécile MichalletJean-Pierre Revillard
Aug 26, 2000·Transplant International : Official Journal of the European Society for Organ Transplantation·H KauppinenI Lautenschlager
Jul 22, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Hideki MotoyamaHiroshi Date
Feb 26, 2010·Mediators of Inflammation·Ali AkcayCharles L Edelstein
Mar 29, 2011·Transplantation Proceedings·H KrichenY Gorgi
Mar 3, 2009·Transplantation Proceedings·L DomanskiK Ciechanowski
Sep 4, 2008·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Volkmar LangeOlaf Elert
Oct 24, 2007·Transplantation Proceedings·D KhazenK Ayed
Dec 2, 2006·Transplant Immunology·P J Yates, M L Nicholson
Apr 14, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S WeissJ Pratschke
Dec 2, 2006·Transplant Immunology·Fadi SabbaghMichèle German-Fattal
Dec 2, 2006·Transplant Immunology·L DomańskiK Ciechanowski
Jul 16, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Shufeng TanNiansong Wang
Aug 23, 2001·The Journal of Surgical Research·S I JungC F Freise
Nov 19, 2004·Journal of Leukocyte Biology·Karyn Yonekawa, John M Harlan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.