PMID: 9160896Apr 1, 1997Paper

Cell-adhesion molecules in human meningiomas: correlation with clinical and morphological data

Neuropathology and Applied Neurobiology
D Figarella-BrangerJ F Pellissier

Abstract

Integrins form a family of cell adhesion molecules. CD44 glycoproteins are found in a wide variety of isoforms; the most common, CD44s (standard) is widely distributed, and functions as an adhesion molecule. In this study, we have investigated immunohistochemically the distribution of some VLA integrins (alpha2, alpha5 and alpha6 chains of beta1 integrins) and CD44s in 44 meningioma specimens and normal arachnoid villi. Meningiomas were of meningothelial (16), transitional (13) and fibroblastic (15) subtypes. There were 13 grade I, 19 grade II and 12 grade III (27%). Immunoprecipitates were quantified by image analysis and correlated with clinical (age, sex, location) and morphological data (histological subtypes and grades). VLA alpha5 chain was expressed by normal arachnoid villi (mainly cap cells) and by 42 out of 44 meningioma specimens. Expression was lower in fibroblastic meningiomas (P=0.02). VLA alpha2 and alpha6 chains were not observed in normal arachnoid villi. VLA alpha2 was expressed by 15 meningiomas, VLA alpha6 by 10. Interestingly, meningiomas expressing either VLA alpha2 or alpha6 were usually of grade III (P< or =(0.05). CD44s was found on various parts of arachnoid villi and in all meningiomas although expres...Continue Reading

References

Jan 1, 1992·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·A Bignami, R Asher
Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·G R ScreatonJ I Bell
Feb 20, 1992·International Journal of Cancer. Journal International Du Cancer·M C KuppnerN de Tribolet
Oct 18, 1991·Cell·M BevilacquaR McEver
Jan 1, 1991·The Journal of Clinical Investigation·E Ruoslahti
Oct 13, 1989·Science·N Sharon, H Lis
Dec 1, 1989·Immunology Today·B F HaynesS M Denning
Jan 1, 1988·Annual Review of Immunology·A F Williams, A N Barclay
Oct 1, 1993·Current Opinion in Cell Biology·R L Juliano, J A Varner
Mar 11, 1993·Nucleic Acids Research·C TölgH Ponta
Dec 1, 1964·Journal of Neurosurgery·R R STRANGEH NORDENSTAM

❮ Previous
Next ❯

Citations

Sep 18, 2012·The American Journal of Pathology·Patrícia H DominguesMaria D Tabernero
Nov 10, 2010·PloS One·Laura J Lewis-TuffinPanos Z Anastasiadis
May 20, 1998·The Australian and New Zealand Journal of Psychiatry·J Read, A Fraser
Apr 7, 2018·Acta Histochemica Et Cytochemica·Younosuke SatoTakaaki Ito
May 6, 2011·Pediatric Radiology·Jacques F Schneider

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.