Abstract
Integrins form a family of cell adhesion molecules. CD44 glycoproteins are found in a wide variety of isoforms; the most common, CD44s (standard) is widely distributed, and functions as an adhesion molecule. In this study, we have investigated immunohistochemically the distribution of some VLA integrins (alpha2, alpha5 and alpha6 chains of beta1 integrins) and CD44s in 44 meningioma specimens and normal arachnoid villi. Meningiomas were of meningothelial (16), transitional (13) and fibroblastic (15) subtypes. There were 13 grade I, 19 grade II and 12 grade III (27%). Immunoprecipitates were quantified by image analysis and correlated with clinical (age, sex, location) and morphological data (histological subtypes and grades). VLA alpha5 chain was expressed by normal arachnoid villi (mainly cap cells) and by 42 out of 44 meningioma specimens. Expression was lower in fibroblastic meningiomas (P=0.02). VLA alpha2 and alpha6 chains were not observed in normal arachnoid villi. VLA alpha2 was expressed by 15 meningiomas, VLA alpha6 by 10. Interestingly, meningiomas expressing either VLA alpha2 or alpha6 were usually of grade III (P< or =(0.05). CD44s was found on various parts of arachnoid villi and in all meningiomas although expres...Continue Reading
References
Jan 1, 1992·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·A Bignami, R Asher
Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·G R ScreatonJ I Bell
Feb 20, 1992·International Journal of Cancer. Journal International Du Cancer·M C KuppnerN de Tribolet
Apr 3, 1992·Cell·R O Hynes
Feb 1, 1990·The Journal of Cell Biology·S Dedhar, R Saulnier
Jun 29, 1990·Cell·A AruffoB Seed
Oct 18, 1991·Cell·M BevilacquaR McEver
Jan 1, 1991·The Journal of Clinical Investigation·E Ruoslahti
Jan 1, 1991·Journal of the Neurological Sciences·M M Esiri, C S Morris
Aug 1, 1989·The Journal of Cell Biology·L J PickerE C Butcher
Oct 13, 1989·Science·N Sharon, H Lis
Dec 1, 1989·Immunology Today·B F HaynesS M Denning
Jan 1, 1988·Annual Review of Immunology·A F Williams, A N Barclay
Sep 1, 1988·Journal of Neurosurgery·S KidaS Yamamoto
Aug 1, 1985·Surgical Neurology·J JääskeläinenS Valtonen
Feb 1, 1993·Histopathology·H K NG, A T Wong
Oct 1, 1993·Current Opinion in Cell Biology·R L Juliano, J A Varner
Apr 15, 1993·Cancer·K Shanmugaratnam, L H Sobin
Mar 11, 1993·Nucleic Acids Research·C TölgH Ponta
Dec 1, 1964·Journal of Neurosurgery·R R STRANGEH NORDENSTAM
Citations
May 5, 2010·Journal of Cancer Research and Clinical Oncology·Pedro DuenischSusanne A Kuhn
Mar 8, 2011·Cancer·Ari J KaneAndrew T Parsa
Sep 18, 2012·The American Journal of Pathology·Patrícia H DominguesMaria D Tabernero
Nov 10, 2010·PloS One·Laura J Lewis-TuffinPanos Z Anastasiadis
Dec 3, 2010·Veterinary Pathology·T IdeH Nakayama
May 20, 1998·The Australian and New Zealand Journal of Psychiatry·J Read, A Fraser
Jan 19, 2006·Glia·Amy RasleyIan Marriott
Apr 7, 2018·Acta Histochemica Et Cytochemica·Younosuke SatoTakaaki Ito
May 6, 2011·Pediatric Radiology·Jacques F Schneider