Abstract
P-cadherin (CDH3) and CD24 are cell adhesion molecules that control morphogenic processes, cell motility, and invasive growth of tumor cells. The aim of our study was to investigate P-cadherin and CD24 expression in carcinomas and dysplastic lesions of the biliary tract and to evaluate the potential diagnostic usefulness of these cell adhesion molecules. Using immunohistochemistry on tissue microarrays, we analyzed P-cadherin, CD24, and p53 expression in 117 carcinomas of the biliary tract (19 intrahepatic cholangiocarcinomas, 59 extrahepatic cholangiocarcinomas, and 39 gallbladder carcinomas) and correlated our findings with clinicopathologic parameters. We found P-cadherin positivity in 37% of intrahepatic cholangiocarcinomas, 73% of extrahepatic cholangiocarcinomas, and 64% of gallbladder carcinomas, respectively. CD24 reactivity was observed in 21% of intrahepatic cholangiocarcinomas, 58% of extrahepatic cholangiocarcinomas, and 42% of gallbladder carcinomas. Nuclear p53 expression was found in 37% of intrahepatic cholangiocarcinomas, 46% of extrahepatic cholangiocarcinomas, and 45% of gallbladder carcinomas. We also studied P-cadherin, CD24, and p53 expression in normal (n = 30), inflamed (n = 22), and dysplastic (n = 21) ...Continue Reading
References
Sep 1, 1994·Cancer·M TehG C Raju
Jul 14, 1998·Nature Medicine·J KononenO P Kallioniemi
Nov 7, 2000·Cancer·A C HanH Salazar
May 9, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K HaradaY Nakanuma
Mar 13, 2002·Gut·R G HardyJ A Z Jankowski
Oct 9, 2002·The American Journal of Pathology·Glen KristiansenSteffen Hauptmann
Jun 12, 2003·International Journal of Cancer. Journal International Du Cancer·Ila S PatelColin D MacCalman
Jan 13, 2004·The Prostate·Glen KristiansenManfred Dietel
Mar 3, 2004·Pathology International·Koichi TsuneyamaYasuni Nakanuma
Sep 3, 2004·Nature Reviews. Cancer·Ignacio I Wistuba, Adi F Gazdar
Dec 25, 2004·Journal of Hepato-biliary-pancreatic Surgery·Hideo ChibaKen Saito
May 10, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kazutaka ObamaYoichi Furukawa
Aug 24, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Joana ParedesFernando C Schmitt
Aug 30, 2005·Cancer Letters·Min-Cheng SuYung-Ming Jeng
Sep 17, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Wilko WeichertGlen Kristiansen
Oct 11, 2005·Lancet·Shahid A KhanSimon D Taylor-Robinson
Mar 25, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Donna E HanselPedram Argani
May 26, 2006·Nature·Gerhard Christofori
Jul 11, 2006·Pathology, Research and Practice·Sema BircanOzden Candir
Aug 8, 2006·Gastroenterology·Eyal SagivNadir Arber
Oct 13, 2006·Gastroenterology·Laura E Moreno LunaGregory J Gores
Jan 24, 2007·Human Pathology·Ryan D DeHaanKevin C Halling
Aug 8, 2007·Annals of Surgical Oncology·Yuh-Yu ChouRay-Hwang Yuan
Apr 4, 2008·Urology·Hyun Ju LeeKyung Chul Moon
Dec 2, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Daniel BaumhoerLuigi M Terracciano
Dec 4, 2008·Annals of Surgical Oncology·Akihiko SanoHiroyuki Kuwano
May 27, 2009·Human Pathology·Marc-Oliver RienerGlen Kristiansen
Citations
Mar 7, 2012·Langenbeck's Archives of Surgery·Lena SibuleskyTushar Patel
Jun 30, 2012·Journal of Biomedicine & Biotechnology·Jia LiFang Gong
Mar 30, 2013·World Journal of Gastroenterology : WJG·Kyubo KimSung W Ha
Oct 20, 2012·Human Pathology·Jianhui ShiFan Lin
Aug 12, 2014·The American Journal of Pathology·Catherine M WestbomArti Shukla
Apr 26, 2013·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Ahmad A AbdulmajeedCamile S Farah
Aug 22, 2012·Journal of Hepato-biliary-pancreatic Sciences·Toshio KokuryoMasato Nagino
Feb 18, 2014·Journal of Hepato-biliary-pancreatic Sciences·Takeshi ItoYoshinori Murakami
May 3, 2014·Journal of Gastroenterology and Hepatology·Jimme K WiggersThomas M van Gulik
Dec 17, 2014·Virchows Archiv : an International Journal of Pathology·Yoshiko KeiraTadashi Hasegawa
Dec 31, 2014·Archives of Pathology & Laboratory Medicine·Fan LinHanlin L Wang
Jan 6, 2017·Archives of Pathology & Laboratory Medicine·Michelle D ReidN Volkan Adsay
Feb 23, 2012·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·Yong ShiYang Wang
Sep 21, 2011·The American Journal of Gastroenterology·Pawel K MazurJens T Siveke
Apr 25, 2012·Medical Oncology·Haofei WangXuhui Gao
Dec 3, 2011·Medical Oncology·Shi-peng SongZhe-hai Li
May 13, 2020·Molecular Oncology·Jie SunQing Shao
Oct 21, 2020·International Journal of Molecular Sciences·Ilona KaszakPiotr Jurka
May 1, 2021·Cancer Cell·Silvia AffoRobert F Schwabe