Cell apoptosis and regeneration of hepatocellular carcinoma after transarterial chemoembolization

World Journal of Gastroenterology : WJG
Zhen LiYan-Rong Huang

Abstract

To evaluate whether cell apoptosis and regeneration were existed in normal liver cells adjacent to carcinoma after transarterial chemoembolization (TACE). Fifty rabbits with hepatic carcinoma were divided into 5 groups at random: group A (control group), groups B and C (TACE treatment groups), groups D and E (partial hepatectomy groups). There were 10 rabbits in each group. Rabbits in groups B-E were treated by transarterial chemoembolization (TACE) and partial hepatectomy (PH) respectively. The changes of S-phase cell fraction (SPF), proliferation index (PI) and cell apoptosis in the normal liver tissue were determined with flow cytometry (FCM) after operations on the first and third days. We determined the mitosis index (MI) with histo-pathological method and the apoptosis index (AI) with TUNEL method at the same time. Twenty-four hours after operations, compared with control group, the rabbits in TACE group had much higher index of SPF, PI and MI (MI: t=4.89, P<0.001; SPF:t=5.27, P<0.001; PI: t=4.87, P<0.001). Moreover, the proliferation of liver cells in TACE group was much weaker than that of the cells treated by partial hepatectomy, and the differences were significant (MI: t=7.02, P<0.001; SPF: t=4.06, P<0.001; PI: t=2.7...Continue Reading

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Citations

Dec 25, 2010·Therapeutic Advances in Gastroenterology·Markus Peck-Radosavljevic
Nov 3, 2020·Frontiers in Cell and Developmental Biology·Maojiao LiWeidong Tian
Oct 28, 2010·Science Signaling·Andreas Bergmann, Hermann Steller

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