PMID: 3214654Jul 1, 1988Paper

Cell attachment of human gingival fibroblasts in vitro to porous-surfaced titanium alloy discs coated with collagen and platelet-derived growth factor

Biomaterials
B F LowenbergA H Melcher

Abstract

The influence of biological coating, with or without the incorporation of growth factor, on the migration, attachment and orientation of human gingival fibroblasts in relation to porous-surfaced titanium alloy (Ti6AI4V) discs, was measured. Comparison was made between coating the discs with collagen and with collagen incorporating platelet-derived growth factor (PDGF); controls comprised porous-surfaced discs coated with agar or collagen containing bovine serum albumin (used as a carrier for the PDGF), uncoated porous-surfaced Ti6AI4V discs (with or without additional protein additives) exhibited significantly higher attachment indices (AI) and orientation indices (OI) compared with naked control discs (p less than 0.01); OI was also significantly higher than that of surface-demineralized root slices (p less than 0.001) on days 1, 2 and 3. Addition of PDGF to the collagen resulted in a further enhancement in OI on days 1 and 2 (p less than 0.01) over that shown by discs coated with collagen incorporating the bovine serum albumin vehicle. There was no cell attachment and consequently, no cell orientation, in relation to Ti alloy discs that had been coated with agar. These data suggest that attachment and orientation of cells fol...Continue Reading

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Citations

Jul 6, 2000·Journal of Biomedical Materials Research·U GeisslerK Wenzel
Aug 19, 2007·Journal of Materials Science. Materials in Medicine·Bernd StadlingerUwe Eckelt
Oct 21, 2003·Journal of Biomedical Materials Research. Part a·Susanne BierbaumHartmut Worch
Oct 1, 1992·The Journal of the American Dental Association·S G CiancioR Shafer
Aug 15, 2014·Colloids and Surfaces. B, Biointerfaces·Nathalia Marín-ParejaMaria-Pau Ginebra
Feb 15, 2008·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Y LiuK de Groot
Apr 1, 1993·The Journal of Prosthetic Dentistry·M Edgerton, M J Levine

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