Cell-based and cytokine-directed chemical screen to identify potential anti-multiple myeloma agents.

Leukemia Research
Rentian FengSuzanne Lentzsch

Abstract

We used a novel high-throughput drug screening assay, based on Luminex technology, to identify anti-myeloma agents capable of inhibiting cytokines and growth factors essential for multiple myeloma (MM) from a chemical library of 1120 compounds provided by MMRF. Tetracycline derivatives inhibited MM cell proliferation and osteoclast activating factors without obvious effect on cell viability. Steroid compounds specifically decreased angiogenesis-related factors, but stimulated osteoclast activating factors. Antihelmintic drugs potently inhibited cytokines and were cytotoxic. The screen identified potential candidates with potent anti-MM properties that need further investigation.

References

Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C HeligeH A Tritthart
Mar 20, 2004·Lancet·Bhawna Sirohi, Ray Powles
Mar 27, 2004·Cancer Treatment and Research·G David Roodman, Sun Jin Choi
Apr 13, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Elieser GorelikAnna E Lokshin
Mar 23, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mohammad Hossein PourgholamiDavid Lawson Morris
Jun 13, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Constantine S MitsiadesKenneth C Anderson
Jun 27, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Kurt BommertThorsten Stühmer
Sep 20, 2006·Experimental Hematology·Rohit AggarwalG David Roodman
Sep 21, 2006·Molecular Cancer Therapeutics·Kenneth W YipFei-Fei Liu
Oct 26, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Akihiro YanoKazunori Kihara
May 26, 2007·Biochimica Et Biophysica Acta·Andrey KulikovGeorgios Scheiner-Bobis
Oct 24, 2007·Clinical & Experimental Metastasis·Isabelle Vande BroekIvan Van Riet
Oct 31, 2007·Advances in Experimental Medicine and Biology·Hyun-Ju KimSteven L Teitelbaum
Nov 13, 2007·Hematology/oncology Clinics of North America·Suzanne LentzschG David Roodman
Nov 16, 2007·The New England Journal of Medicine·Philip N Sambrook
Aug 1, 2008·Molecular Cancer Research : MCR·Nicole DoudicanSeth J Orlow
Aug 13, 2008·International Journal of Cancer. Journal International Du Cancer·Vera LevinaElieser Gorelik

❮ Previous
Next ❯

Citations

Nov 6, 2015·Congenital Anomalies·Yuhei NishimuraToshio Tanaka
Apr 30, 2013·Journal of Ethnopharmacology·Qiu-Xia MengJane R Hanrahan
Aug 10, 2011·Molecular Cancer Therapeutics·Rentian FengSuzanne Lentzsch

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Glycosides

Cardiac glycosides are a diverse family of naturally derived compounds that bind to and inhibit na+/k+-atpase. Discover the latest research on cardiac glycosides heres.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.