Cell-Based and Exosome Therapy in Diabetic Stroke

Stem Cells Translational Medicine
Poornima VenkatJieli Chen

Abstract

Stroke is a global health concern and it is imperative that therapeutic strategies with wide treatment time frames be developed to improve neurological outcome in patients. Patients with diabetes mellitus who suffer a stroke have worse neurological outcomes and long-term functional recovery than nondiabetic stroke patients. Diabetes induced vascular damage and enhanced inflammatory milieu likely contributes to worse post stroke outcomes. Diabetic stroke patients have an aggravated pathological cascade, and treatments that benefit nondiabetic stroke patients do not necessarily translate to diabetic stroke patients. Therefore, there is a critical need to develop therapeutics for stroke specifically in the diabetic population. Stem cell based therapy for stroke is an emerging treatment option with wide therapeutic time window. Cell-based therapies for stroke promote endogenous central nervous system repair and neurorestorative mechanisms such as angiogenesis, neurogenesis, vascular remodeling, white matter remodeling, and also modulate inflammatory and immune responses at the local and systemic level. Emerging evidence suggests that exosomes and their cargo microRNA mediate cell therapy derived neurorestorative effects. Exosomes a...Continue Reading

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Citations

May 18, 2019·Stem Cells Translational Medicine·Cesario V Borlongan
Jul 10, 2019·Restorative Neurology and Neuroscience·T L MooreB Buller
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Nov 4, 2020·Current Pharmaceutical Design·Stavroula A PaschouDimitrios Tousoulis

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Clinical Trials Mentioned

NCT01922908
NCT01678534
NCT02580019
NCT02397018
NCT03004976
NCT03384433
NCT03371329

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