Cell-Based Assays on Microfluidics for Drug Screening

ACS Sensors
Xiaoyan LiuXingyu Jiang

Abstract

Microfluidics is an appealing platform for drug screening and discovery. Compared with the conventional drug screening methods based on Petri dishes and experimental animals, microfluidic devices have many advantages including miniaturized size, ease-to-use, high sensitivity, and high throughput. More importantly, bioassays on microfluidics can avoid ethical issues which can be a big obstacle hindering the performance of the experiments on animals or human being. Furthermore, three-dimensional (3D) microchips can recapitulate various biochemical and biophysical conditions in vivo and mimic the natural microenvironment of the tissues/organs, providing versatile in vitro models for biomedical applications. In this Perspective, we will focus on the cell-based microfluidic assays for drug screening. Meanwhile, we also propose potential solutions for the difficulties in this field and discuss the prospects of microfluidics-based technologies for drug screening.

References

May 2, 2003·Journal of the American Chemical Society·Xingyu JiangGeorge M Whitesides
Apr 5, 2005·Toxicologic Pathology·Sushil K ThukralCynthia A Afshari
Aug 12, 2005·Nature Methods·Anne M TaylorNoo Li Jeon
Jul 28, 2006·Nature·George M Whitesides
Nov 22, 2007·Lab on a Chip·Nannan YeBingcheng Lin
Jun 12, 2009·Analytical Chemistry·Donald WlodkowicJonathan M Cooper
Jun 26, 2010·Science·Dongeun HuhDonald E Ingber
Oct 23, 2010·Lab on a Chip·Sara Lindström, Helene Andersson-Svahn
Aug 3, 2011·Proceedings of the National Academy of Sciences of the United States of America·Milena D LazovaThomas S Shimizu
Oct 19, 2011·Current Opinion in Genetics & Development·Alexander Loewer, Galit Lahav
Jul 10, 2012·Integrative Biology : Quantitative Biosciences From Nano to Macro·Zhenling ChenXingyu Jiang
Jul 24, 2012·Lab on a Chip·Wenfu ZhengXingyu Jiang
Aug 24, 2012·Nature·Claudio Franco, Holger Gerhardt
Oct 9, 2012·Nature Nanotechnology·Pedro M ValenciaRobert Langer
Feb 12, 2013·Integrative Biology : Quantitative Biosciences From Nano to Macro·Wenwen LiuXingyu Jiang
Feb 14, 2013·Lab on a Chip·Ngoc-Duy DinhJonathan West
Feb 26, 2013·PloS One·Jessie S JeonJoseph L Charest
Jun 14, 2013·Nature Reviews. Cancer·Mary Helen Barcellos-HoffTimothy C Wang
Jul 6, 2013·Lab on a Chip·John P WikswoWilliam J Matloff
Feb 27, 2014·Analytical Chemistry·Zeynep Dereli-KorkutSihong Wang
Jan 15, 2015·Nature Communications·Burak DuraJoel Voldman
Mar 21, 2015·Nature Reviews. Drug Discovery·Eric W EschDongeun Huh
Mar 8, 2016·Integrative Biology : Quantitative Biosciences From Nano to Macro·Yifeng LeiXingyu Jiang
Apr 5, 2016·Proceedings of the National Academy of Sciences of the United States of America·Danny BavliYaakov Nahmias
Jun 16, 2016·Proceedings of the National Academy of Sciences of the United States of America·Burak DuraJoel Voldman
Jul 12, 2016·Biotechnology and Bioengineering·Ying I WangMichael L Shuler
Jan 27, 2017·Bioconjugate Chemistry·Dirk van den BrandWouter P R Verdurmen
May 26, 2017·Advanced Healthcare Materials·Minhwan ChungNoo Li Jeon

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Citations

Jan 27, 2021·Stem Cell Research & Therapy·Meixian JinShuqin Zhou
Mar 12, 2021·Biotechnology and Bioengineering·Mingji WeiYecheng Zhang
Dec 15, 2019·Trends in Biotechnology·Emily K Bowman, Hal S Alper
Jul 17, 2021·Advanced Materials·Pengchao ZhangLidong Qin

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