Cell biology of mitotic recombination

Cold Spring Harbor Perspectives in Biology
Michael Lisby, Rodney Rothstein

Abstract

Homologous recombination provides high-fidelity DNA repair throughout all domains of life. Live cell fluorescence microscopy offers the opportunity to image individual recombination events in real time providing insight into the in vivo biochemistry of the involved proteins and DNA molecules as well as the cellular organization of the process of homologous recombination. Herein we review the cell biological aspects of mitotic homologous recombination with a focus on Saccharomyces cerevisiae and mammalian cells, but will also draw on findings from other experimental systems. Key topics of this review include the stoichiometry and dynamics of recombination complexes in vivo, the choreography of assembly and disassembly of recombination proteins at sites of DNA damage, the mobilization of damaged DNA during homology search, and the functional compartmentalization of the nucleus with respect to capacity of homologous recombination.

Citations

Feb 11, 2016·Critical Reviews in Biotechnology·Mario Juhas, James W Ajioka
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May 30, 2017·The Journal of Biological Chemistry·Chu Jian MaEric C Greene
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Aug 11, 2017·Molecular Biology of the Cell·Judith Miné-HattabXavier Darzacq
Nov 4, 2017·Nucleus·Aude Guénolé, Gaëlle Legube
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Feb 20, 2021·Proceedings of the National Academy of Sciences of the United States of America·Guangxue LiuXuefeng Chen
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Mar 12, 2016·Genes & Development·Sonia SilvaMichael Lisby

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