Cell Biology of Tight Junction Barrier Regulation and Mucosal Disease

Cold Spring Harbor Perspectives in Biology
Aaron Buckley, Jerrold R Turner

Abstract

Mucosal surfaces are lined by epithelial cells. In the intestine, the epithelium establishes a selectively permeable barrier that supports nutrient absorption and waste secretion while preventing intrusion by luminal materials. Intestinal epithelia therefore play a central role in regulating interactions between the mucosal immune system and luminal contents, which include dietary antigens, a diverse intestinal microbiome, and pathogens. The paracellular space is sealed by the tight junction, which is maintained by a complex network of protein interactions. Tight junction dysfunction has been linked to a variety of local and systemic diseases. Two molecularly and biophysically distinct pathways across the intestinal tight junction are selectively and differentially regulated by inflammatory stimuli. This review discusses the mechanisms underlying these events, their impact on disease, and the potential of using these as paradigms for development of tight junction-targeted therapeutic interventions.

Citations

Jun 11, 2017·Cold Spring Harbor Perspectives in Biology·Miguel A GarciaNatalie Chavez
Nov 9, 2018·Tissue Barriers·Ashfaqul Alam, Andrew Neish
Aug 30, 2017·Cold Spring Harbor Perspectives in Biology·Ian V BeamishTimothy E Kennedy
Sep 27, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yitang WangLe Shen
Mar 8, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Adam L Edwinson, Madhusudan Grover
Oct 5, 2019·Nature Reviews. Molecular Cell Biology·Kenneth M Yamada, Michael Sixt
Sep 1, 2019·Digestive Diseases and Sciences·Daniel Hollander, Jonathan D Kaunitz
Jan 22, 2020·Annual Review of Immunology·Sean P ColganCormac T Taylor
Apr 15, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ning JiaoJingdong Yin
Sep 10, 2019·Journal of Dental Research·Z LiuY Chen
Jun 21, 2020·Biology of Reproduction·Rodolfo D Vicetti MiguelThomas L Cherpes
Aug 4, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·John W WileyShuangsong Hong
Sep 3, 2020·Journal of Animal Science·Yijie HeYanhong Liu
Oct 6, 2019·Biophysics Reviews·Sandra Citi
Apr 3, 2019·Nature Medicine·J Magarian Blander
Nov 14, 2019·International Journal of Molecular Sciences·Nandhini RajagopalShikha Nangia
May 16, 2020·Frontiers in Immunology·Andreas FreyMichael Wegmann
Apr 22, 2020·Tissue Barriers·Grace C LinWinfried Neuhaus
Sep 28, 2018·Intensive Care Medicine Experimental·David VermetteRichard W Pierce
Sep 10, 2020·International Journal of Molecular Sciences·Bénédicte Allam-NdoulAlain Veilleux
Sep 4, 2020·The Journal of Experimental Medicine·Lara Labarta-BajoElina I Zúñiga
May 24, 2020·International Journal of Molecular Sciences·Younggeon Jin, Anthony T Blikslager
Mar 29, 2018·Science·Sandra Citi
Apr 25, 2020·Food Science & Nutrition·Caimei HeXiaoping Yang
Jun 23, 2020·Mediators of Inflammation·Jing GaoYuLong Yin

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