Cell-block procedure in endoscopic ultrasound-guided-fine-needle-aspiration of gastrointestinal solid neoplastic lesions

World Journal of Gastrointestinal Endoscopy
Antonio IeniGiovanni Tuccari

Abstract

In the present review we have analyzed the clinical applications of endoscopic ultrasound-guided-fine-needle-aspiration (EUS-FNA) and the methodological aspects obtained by cell-block procedure (CBP) in the diagnostic approach to the gastrointestinal neoplastic pathology. CBP showed numerous advantages in comparison to the cytologic routine smears; in particular, better preservation of cell architecture, achievement of routine haematoxylin-eosin staining equivalent to histological slides and possibility to perform immunohistochemistry or molecular analyses represented the most evident reasons to choose this method. Moreover, by this approach, the differential diagnosis of solid gastrointestinal neoplasias may be more easily achieved and the background of contaminant non-neoplastic gastrointestinal avoided. Finally, biological samples collected by EUS-FNA CBP-assisted should be investigated in order to identify and quantify further potential molecular markers.

Citations

Nov 23, 2017·The Korean Journal of Internal Medicine·Michael HockeChristoph F Dietrich
Jun 7, 2018·Cytopathology : Official Journal of the British Society for Clinical Cytology·G AngelicoG Tuccari
Sep 16, 2018·Cytopathology : Official Journal of the British Society for Clinical Cytology·César Vivian LopesAntônio Atalíbio Hartmann
Sep 22, 2016·CytoJournal·Antonio IeniGiovanni Tuccari
Sep 4, 2020·World Journal of Gastrointestinal Endoscopy·Lawrence KuSofiya Reicher
Aug 28, 2021·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Moon Jae ChungJoo Young Cho

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