Cell blocks in cytopathology: An update

Cytopathology : Official Journal of the British Society for Clinical Cytology
Aruna Nambirajan, Deepali Jain

Abstract

The cell block (CB) offers many advantages over other cytological preparations, particularly for immunocytochemical and molecular testing. However, inconsistent cellularity remains the most common reason for dissatisfaction among cytopathologists. In recent years, there has been a surge in the demand for CBs imposed by the increasing number of minimally invasive procedures performed to obtain material for diagnostic, prognostic and predictive purposes from advanced stage cancer patients. However, routine preparation of CBs significantly increases laboratory work load, operating cost and sample turn-around time. The objectives of our review were to: (a) identify scenarios where a CB is likely to improve diagnostic yield; (b) optimise CB preparatory methods; and (c) understand the factors influencing the success and validity of ancillary testing on various types of CBs. We performed an extensive literature search on CBs in cytology on internet search engines using the following keywords: cell block, cytoblock, cytology, cytopathology, methods, preparation, fixatives, diagnostic yield, ancillary and molecular studies. New CB methods, improvisations of previous CB methods, their utility for diagnosis, immunocytochemistry and molecu...Continue Reading

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Citations

May 3, 2019·Cancer Cytopathology·Deepali JainUNKNOWN IASLC Pathology Committee
Apr 26, 2020·Diagnostic Cytopathology·Elena VigliarGiancarlo Troncone
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Dec 29, 2020·Archives of Pathology & Laboratory Medicine·Elizabeth M JacobiSinchita Roy-Chowdhuri
May 7, 2021·Cytopathology : Official Journal of the British Society for Clinical Cytology·Antonino IaccarinoElena Vigliar
Jun 28, 2021·Revista española de patología : publicación oficial de la Sociedad Española de Anatomía Patológica y de la Sociedad Española de Citología·Iñigo GorostiagaAlvaro Perez-Rodriguez
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Sep 9, 2021·Cytopathology : Official Journal of the British Society for Clinical Cytology·Deepali Jain, Lukas Bubendorf
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Sep 2, 2019·Acta Cytologica·Heli Hakso-Mäkinen, Ivana Kholová
Oct 31, 2021·Cytopathology : Official Journal of the British Society for Clinical Cytology·Anthony Maddox, Louise M Smart

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