Cell-cell adhesion molecules in Dictyostelium

BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology
C H Siu

Abstract

Multicellularity in the cellular slime mold Dictyostelium discoideum is achieved by the expression of two types of cell-cell adhesion sites. The EDTA-sensitive adhesion sites are expressed very early in the development cycle and a surface glycoprotein of 24,000 Da is known to be responsible for these sites. The EDTA-resistant contact sites begin to accumulate on the cell surface at the aggregation stage of development. Several glycoproteins have been implicated in the EDTA-resistant type of cell-cell binding and the best characterized one has an Mr of 80,000 (gp80). gp80 mediates cell-cell binding via homophilic interaction and its cell binding site has been mapped to an octapeptide sequence. The mechanism by which gp80 mediates cell-cell adhesion will be discussed.

References

Sep 1, 1978·The Journal of Cell Biology·W R Springer, S H Barondes
Jan 1, 1990·Developmental Genetics·C H Siu, R K Kamboj
Jan 1, 1988·Annual Review of Biochemistry·M A Ferguson, A F Williams
Oct 1, 1988·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·C H SiuA Cho
Jan 1, 1988·Developmental Genetics·W F Loomis
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·H SadeghiC Klein
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J J HemperlyB A Cunningham
May 1, 1987·Developmental Biology·D A KnechtW F Loomis
Jan 1, 1985·Annual Review of Biochemistry·R Kornfeld, S Kornfeld
Jun 1, 1972·Experimental Cell Research·D R Garrod
Jun 1, 1982·Developmental Biology·J A Schmidt, W F Loomis
Jan 1, 1980·Current Topics in Developmental Biology·G Gerisch
Oct 1, 1982·Developmental Biology·D S CoffmanH V Rickenberg
Nov 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·C H SiuT Y Lam
Dec 1, 1980·The Journal of Cell Biology·W R Springer, S H Barondes
Jan 1, 1981·Journal of Supramolecular Structure and Cellular Biochemistry·B A MurrayW F Loomis
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·L M Wong, C H Siu
Dec 1, 1981·Differentiation; Research in Biological Diversity·T Y LamC H Siu

❮ Previous
Next ❯

Citations

May 1, 1997·Developmental Biology·J T StegeW F Loomis
Jun 7, 1994·Proceedings of the National Academy of Sciences of the United States of America·M Di CarloG Ghersi
Apr 23, 2008·Journal of the Royal Society, Interface·Wonhee Jang, Richard H Gomer
Apr 7, 2004·Development, Growth & Differentiation·Satomi MatsuokaMineko Maeda
Dec 1, 1993·Artificial Organs·K von AppenH Klinkmann
Nov 25, 2004·Seminars in Cell & Developmental Biology·Chi-Hung SiuEstella Wong
Jul 1, 1992·Journal of Cellular Physiology·C H SiuI B Fritz
Nov 23, 2000·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·R BruinsmaE Sackmann

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.