PMID: 8971342Jan 1, 1996Paper

Cell-cell interactions and segmentation in the developing vertebrate hindbrain

Biochemical Society Symposium
C IrvingD G Wilkinson

Abstract

During development of the vertebrate hindbrain, regulatory gene expression becomes precisely restricted to specific segments. Studies at the cellular and molecular levels suggest that establishment of this precise pattern of gene expression may involve a dynamic regulation of cell identity and a restriction of cell movement across rhombomere boundaries. Candidates for mediating such interactions are several members of the Eph-related receptor tyrosine kinase (RTK) family that have segmental expression in the hindbrain. Ligands for members of this RTK family are membrane-bound, and may therefore mediate cell contact-dependent signalling. We discuss the expression patterns of Eph-related receptors in the hindbrain and the potential roles that these may play in patterning.

Related Concepts

Related Feeds

Actin, Myosin & Cell Movement

Contractile forces generated by the actin-myosin cytoskeleton are critical for morphogenesis, but the cellular and molecular mechanisms of contraction have been elusive for many cell shape changes and movements. Here is the latest research on the roles of actin and myosin in cell movement.