Cell Chirality Induces Collective Cell Migration in Epithelial Sheets

Physical Review Letters
Katsuhiko SatoTatsuo Shibata

Abstract

During early development, epithelial cells form a monolayer sheet and migrate in a uniform direction. Here, we address how this collective migration can occur without breaking the cell-to-cell attachments. Repeated contraction and expansion of the cell-to-cell interfaces enables the cells to rearrange their positions autonomously within the sheet. We show that when the interface tension is strengthened in a direction that is tilted from the body axis, cell rearrangements occur in such a way that unidirectional movement is induced. We use a vertex model to demonstrate that such anisotropic tension can generate the unidirectional motion of cell sheets. Our results suggest that cell chirality facilitates collective cell migration during tissue morphogenesis.

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Citations

Jan 10, 2017·Soft Matter·Huijun JiangZhonghuai Hou
Oct 11, 2017·Journal of Physics D: Applied Physics·Brian A Camley, Wouter-Jan Rappel
Nov 22, 2018·Proceedings of the National Academy of Sciences of the United States of America·Poulomi RayLeo Q Wan
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Aug 5, 2017·Frontiers in Cell and Developmental Biology·Tetsuya HiraiwaTatsuo Shibata
Apr 19, 2018·Frontiers in Cell and Developmental Biology·Mikiko InakiKenji Matsuno
Jun 13, 2018·ELife·Mikiko InakiHisao Honda
Feb 26, 2019·Biophysical Journal·Satoru OkudaKatsuhiko Sato
May 11, 2021·Proceedings of the National Academy of Sciences of the United States of America·Teije C MiddelkoopStephan W Grill

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