Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12

Xiaochen WangDing Xue


During apoptosis, phosphatidylserine, which is normally restricted to the inner leaflet of the plasma membrane, is exposed on the surface of apoptotic cells and has been suggested to act as an "eat-me" signal to trigger phagocytosis. It is unclear how phagocytes recognize phosphatidylserine. Recently, a putative phosphatidylserine receptor (PSR) was identified and proposed to mediate recognition of phosphatidylserine and phagocytosis. We report that psr-1, the Caenorhabditis elegans homolog of PSR, is important for cell corpse engulfment. In vitro PSR-1 binds preferentially phosphatidylserine or cells with exposed phosphatidylserine. In C. elegans, PSR-1 acts in the same cell corpse engulfment pathway mediated by intracellular signaling molecules CED-2 (homologous to the human CrkII protein), CED-5 (DOCK180), CED-10 (Rac GTPase), and CED-12 (ELMO), possibly through direct interaction with CED-5 and CED-12. Our findings suggest that PSR-1 is likely an upstream receptor for the signaling pathway containing CED-2, CED-5, CED-10, and CED-12 proteins and plays an important role in recognizing phosphatidylserine during phagocytosis.


Sep 5, 2006·Apoptosis : an International Journal on Programmed Cell Death·Dmitri V KryskoPeter Vandenabeele
Mar 18, 2009·Apoptosis : an International Journal on Programmed Cell Death·John F FullardNicholas E Baker
Jun 28, 2005·Progress in Lipid Research·Jean E Vance, Rineke Steenbergen
Jul 13, 2013·Trends in Genetics : TIG·Eva Gómez-OrteJuan Cabello
Jan 4, 2008·Neuron Glia Biology·Mary A Logan, Marc R Freeman
Jun 8, 2010·Nature Cell Biology·Rachael Rutkowski, Anton Gartner
Feb 17, 2005·Nature Reviews. Molecular Cell Biology·Jerry E Chipuk, Douglas R Green
Dec 13, 2005·Cell Death and Differentiation·B Fadeel, Ding Xue
Aug 4, 2010·Proceedings of the National Academy of Sciences of the United States of America·Xia HongGongyi Zhang
Oct 27, 2004·The Journal of Experimental Medicine·Attilio BondanzaMartin Herrmann
Oct 17, 2008·Molecular Biology of the Cell·Hui XiaoChonglin Yang
May 15, 2009·Molecular Biology of the Cell·Ernest HoLina Dagnino
Oct 20, 2007·Science·Bingsheng ChangRichard K Bruick
Oct 12, 2004·Annual Review of Cell and Developmental Biology·Peter W Reddien, H Robert Horvitz
Mar 18, 2005·Annual Review of Immunology·P R TaylorS Gordon
Apr 17, 2008·The Journal of Clinical Investigation·Takaharu IchimuraJoseph V Bonventre
Jul 1, 2004·Arthritis Research & Therapy·Marina Botto
Sep 30, 2004·Journal of Biology·Patrick Williamson, Robert A Schlegel
Feb 16, 2016·Cell Reports·Annika L A NicholsMassimo A Hilliard
Aug 5, 2015·The Journal of Cell Biology·Shiya ChengXiaochen Wang
Sep 29, 2009·Critical Reviews in Biochemistry and Molecular Biology·B Fadeel, Ding Xue
Sep 4, 2007·Trends in Cell Biology·Jean-François Côté, Kristiina Vuori
Aug 8, 2007·Medical Hypotheses·E Sun
Dec 2, 2006·Experimental Cell Research·Takayuki KuraishiYoshinobu Nakanishi
Feb 9, 2005·Journal of Cellular Physiology·Shin AkakuraRaymond B Birge
Oct 1, 2004·The EMBO Journal·Satoshi IshimaruHidesaburo Hanafusa
Aug 18, 2004·Immunology·Christopher D Gregory, Andrew Devitt
Mar 26, 2005·Molecular Reproduction and Development·Akihisa NakagawaYoshinobu Nakanishi
Jun 7, 2005·Biotechnology and Bioengineering·Ying NieSean P Palecek
May 23, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Takashi TakeuchiShunzo Kondo
Nov 30, 2005·Journal of Internal Medicine·B Fadeel, S Orrenius
Oct 21, 2010·Annals of the New York Academy of Sciences·Dror MevorachInna Verbovetski-Reiner
Mar 31, 2005·Seminars in Cell & Developmental Biology·Paolo M Mangahas, Zheng Zhou
Jul 6, 2014·Small GTPases·Susanne Schmidt, Anne Debant
Jun 28, 2005·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Paola Maderna, Catherine Godson
Apr 7, 2016·Cellular and Molecular Life Sciences : CMLS·Xiaochen Wang, Chonglin Yang
Jun 27, 2015·Chemico-biological Interactions·Hyun-Jeong EomJinhee Choi
May 23, 2015·The Biochemical Journal·Angelika BöttgerAlexander Wolf
Aug 26, 2014·The Biochemical Journal·Alena ShmakovaSonia Rocha
Feb 26, 2004·Neuron·Anna R Taylor, Ronald W Oppenheim
May 7, 2013·Methods : a Companion to Methods in Enzymology·Benjamin Lant, W Brent Derry
Jun 2, 2007·Current Biology : CB·Stephanie ZülligMichael O Hengartner
Mar 17, 2010·Current Biology : CB·Tsung-Yuan Hsu, Yi-Chun Wu
Apr 16, 2010·Current Biology : CB·Veera D'mello, Raymond B Birge
Sep 25, 2010·Trends in Cell Biology·Marianne Terndrup Pedersen, Kristian Helin
May 6, 2004·Molecular Cell·Kirsten LauberSebastian Wesselborg
Mar 10, 2010·Cell·Shigekazu NagataKohki Kawane
Jun 19, 2007·Cell·Wei Li, Nicholas E Baker
Oct 30, 2016·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Beatriz Sáenz-NarcisoJuan Cabello
Mar 30, 2004·Anais Da Academia Brasileira De Ciências·Maria Elisabete C Moreira, Marcello A Barcinski
Feb 6, 2018·Annual Review of Immunology·Shigekazu Nagata
Jan 13, 2018·Frontiers in Immunology·Qian ZhengHui Xiao
Apr 28, 2006·Journal of Leukocyte Biology·Shyra J GardaiPeter Henson
Feb 20, 2007·The Journal of Biological Chemistry·Warren L LeeSergio Grinstein
Aug 16, 2016·Genetics·Barbara ConradtDing Xue
Jan 22, 2020·Cell Proliferation·Jing YangXiawei Wei
Sep 11, 2019·Cold Spring Harbor Perspectives in Biology·Andrew J Davidson, Will Wood
May 18, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Seiichiro SakaoNorbert F Voelkel
Apr 1, 2017·Frontiers in Genetics·Janice KwokAndreas Lengeling
Jun 11, 2004·Médecine sciences : M/S·Giovanna Chimini
May 31, 2007·Molecular and Cellular Biochemistry·Nitu TibrewalRaymond B Birge
Jan 19, 2006·Biochemistry. Biokhimii︠a︡·S Ya ProskuryakovA I Kolesnikova
Nov 4, 2005·Biological Research for Nursing·Diana Lithgow, Chandice Covington
Oct 13, 2017·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Shohei Mitani
Oct 23, 2019·Signal Transduction and Targeted Therapy·Heng ZhengXiawei Wei
Sep 3, 2004·The Journal of Biological Chemistry·Junko ManakaYoshinobu Nakanishi
Feb 6, 2017·Amino Acids·Tatyana V KorneenkoMikhail S Shchepinov
Nov 24, 2020·Journal of Molecular Histology·Peiyao LiQian Zheng

Related Concepts

CED-5 protein, C elegans
CED-10 protein, C elegans
Phosphatidylserine receptor
CED-12 protein, C elegans
Psr-1 protein, C elegans
CED-2 protein, C elegans
ELMO2 protein, human
ELMO3 protein, human
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Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis