PMID: 7019665May 26, 1981Paper

Cell culture aging

Molecular and Cellular Biochemistry
M Reff, E L Schneider

Abstract

Cellular research in aging has been stimulated by the observation that human diploid cells have a limited number of cell divisions in culture. This loss of cellular proliferation (in vitro senescence) has been extensively studied by biochemical, clonal, and genetic analysis. Studies of human skin fibroblast cultures have revealed that in vitro senescense is related to in vivo human cellular aging. Recently differentiated cells have been proposed for aging studies. These cells may provide additional information on aging since alterations of in vitro cellular functions may be related to the in vivo behavior of specific differented cell types.

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Citations

Feb 1, 1984·Mechanisms of Ageing and Development·P J Bailey, G C Webster
Nov 1, 1989·Mechanisms of Ageing and Development·M F EthierJ G Dobson
Jan 29, 2009·European Journal of Human Genetics : EJHG·Sofia RodriguezMaria Eriksson
Mar 30, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Sophia L HarrisonMartha M Murray
Nov 6, 2009·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ashley N MastrangeloMartha M Murray
Jan 1, 2014·Forensic Science International : Synergy·Marianne Cathrine RohdeJytte Banner

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