Cell culture processes for monoclonal antibody production.

MAbs
Feng LiAshraf Amanullah

Abstract

Animal cell culture technology has advanced significantly over the last few decades and is now generally considered a reliable, robust and relatively mature technology. A range of biotherapeutics are currently synthesized using cell culture methods in large scale manufacturing facilities that produce products for both commercial use and clinical studies. The robust implementation of this technology requires optimization of a number of variables, including 1) cell lines capable of synthesizing the required molecules at high productivities that ensure low operating cost; 2) culture media and bioreactor culture conditions that achieve both the requisite productivity and meet product quality specifications; 3) appropriate on-line and off-line sensors capable of providing information that enhances process knowledge; and 4) good understanding of culture performance at different scales to ensure smooth scale-up. Successful implementation also requires appropriate strategies for process development, scale-up and process characterization and validation that enable robust operation that is compliant with current regulations. This review provides an overview of the state-of-the art technology in key aspects of cell culture, e.g., engineer...Continue Reading

References

Sep 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S Fukushige, B Sauer
Feb 1, 1995·Applied Biochemistry and Biotechnology·H ChungD W Murhammer
May 1, 1997·Biotechnology Progress·R Kimura, W M Miller
Jan 13, 1998·Nature Genetics·A P Wolffe
Nov 24, 1999·Biotechnology and Bioengineering·H J CruzM J Carrondo
Oct 12, 2000·Biotechnology Progress·S GorfienD Jayme
Oct 10, 2002·Xenotransplantation·Alex Zhu, Rosa Hurst
Dec 6, 2002·Applied Microbiology and Biotechnology·M KitoT Shibui
Feb 8, 2003·Biotechnology Progress·David JonesAbraham Bout
Oct 3, 2003·Proceedings of the National Academy of Sciences of the United States of America·Pam TangvoranuntakulElaine Muchmore
Mar 3, 2004·Biotechnology and Bioengineering·Jing-Xiu BiMohamed Al-Rubeai
May 7, 2004·Applied and Environmental Microbiology·Michael WardHuaming Wang
Oct 7, 2004·Current Opinion in Biotechnology·Dana C Andersen, Dorothea E Reilly
Oct 27, 2004·Biotechnology and Applied Biochemistry·Stephen R FoxDaniel I C Wang
Oct 30, 2004·Biotechnology and Bioengineering·Katsuhiro MoriMitsuo Satoh
Nov 6, 2004·Nature Biotechnology·Arthur J Chirino, Anthony Mire-Sluis
Apr 19, 2005·Applied Microbiology and Biotechnology·Michael Butler
Sep 29, 2005·Biotechnology and Bioengineering·Gargi SethWei-Shou Hu
Nov 24, 2005·Biotechnology and Bioengineering·Peter HarmsGovind Rao
Jan 24, 2006·Nature Biotechnology·Huijuan LiTillman U Gerngross
Apr 7, 2006·Biotechnology and Bioengineering·Tina M SauerwaldMichael J Betenbaugh
Jul 11, 2006·Advanced Drug Delivery Reviews·John R Birch, Andrew J Racher
Aug 26, 2006·Biotechnology and Bioengineering·John E BurkyPaul W Sauer
Oct 13, 2006·Nature Biotechnology·Gary Walsh, Roy Jefferis
Dec 7, 2006·Biotechnology and Bioengineering·Gargi SethWei-Shou Hu
Apr 17, 2007·Nature Biotechnology·Yariv MazorGeorge Georgiou

❮ Previous
Next ❯

Citations

Aug 29, 2012·Applied Microbiology and Biotechnology·Daisuke NishimiyaTohru Takahashi
Nov 13, 2012·Journal of Hematology & Oncology·Michael A Firer, Gary Gellerman
Jan 2, 2014·Molecular Biotechnology·William C YangYao-Ming Huang
Jul 12, 2014·Lab on a Chip·F AbeilleN Picollet-D'hahan
Aug 26, 2014·Journal of Biotechnology·Sohye KangPavel V Bondarenko
Sep 17, 2014·Protein Engineering, Design & Selection : PEDS·Bo YuJames W Larrick
Apr 3, 2013·Applied Biochemistry and Biotechnology·Jun-Young KwonDong-Il Kim
Nov 10, 2015·Immunopharmacology and Immunotoxicology·Simon KrahHarald Kolmar
Jan 13, 2015·Expert Review of Vaccines·Todd J Suscovich, Galit Alter
May 8, 2013·Expert Opinion on Biological Therapy·Tadeusz Robak
Nov 28, 2015·Critical Reviews in Biotechnology·Everardo González-GonzálezAli Khademhosseini
Nov 3, 2015·Biotechnology Advances·Simon FischerKerstin Otte
Nov 13, 2015·Biotechnology Progress·Laurie B HazeltineAnli Ouyang
Jan 27, 2016·Microbial Cell Factories·Anna GaciarzLloyd W Ruddock
Jan 10, 2016·Journal of Chromatography. a·Hong-Fei TongShan-Jing Yao
Apr 26, 2011·New Biotechnology·John H Chon, Gregory Zarbis-Papastoitsis
Mar 5, 2016·Applied Microbiology and Biotechnology·Renate Kunert, David Reinhart
Dec 8, 2015·Applied Microbiology and Biotechnology·Benjamin NeunstoecklinMiroslav Soos
Nov 20, 2012·Biotechnology Journal·Jan HansmannHeike Walles
Oct 31, 2012·Biotechnology and Bioengineering·Lauren FeeneyMichael W Laird
Apr 5, 2012·Biotechnology and Bioengineering·Rashmi KshirsagarThomas Ryll
Nov 15, 2013·Biotechnology Journal·Payel DattaRobert J Linhardt
Feb 28, 2014·Biotechnology Progress·Volker HechtAlexander Jockwer
Feb 28, 2014·Biotechnology Progress·William C YangYao-Ming Huang
Oct 15, 2013·Cell Proliferation·S GottipamulaR N Seetharam
Nov 10, 2015·Biotechnology and Bioengineering·Sofia Fernandes de SousaAlain Vande Wouwer
Nov 5, 2013·Trends in Biotechnology·Oliver SpadiutChristoph Herwig

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
A Rita CostaRosário Oliveira
Biotechnology and Bioengineering
Susan Fugett Abu-AbsiAbhinav A Shukla
© 2021 Meta ULC. All rights reserved